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NSC 33994

Cat. No. 4338 1 Citation Submit a Review Datasheet / COA / SDS

Discontinued Product

4338 has been discontinued.

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Description: JAK2 inhibitor
Chemical Name: E-4,4'-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]phenol
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Pathways (1)
Biological Activity Technical Data Datasheets References

Biological Activity for NSC 33994

NSC 33994 is a selective inhibitor of JAK2 (IC50 = 60 nM). Displays no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.

Technical Data for NSC 33994

M. Wt 438.65
Formula C28H42N2O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 82058-16-0
PubChem ID 5473838
InChI Key QFNJFVBKASKGEU-OCEACIFDSA-N
Smiles CC/C(C2=CC=C(O)C(CN(CC)CC)=C2)=C(CC)\C1=CC(CN(CC)CC)=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for NSC 33994

References are publications that support the biological activity of the product.

Kiss et al (2009) Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening. Bioorg.Med.Chem.Lett. 19 3598 PMID: 19447617

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Keywords: NSC 33994, NSC 33994 supplier, NSC33994, jak2, janus, tyrosine, kinase, inhibitors, inhibits, JAK, Kinase, 4338, Tocris Bioscience

1 Citation for NSC 33994

Citations are publications that use Tocris products. Selected citations for NSC 33994 include:

Zhu et al (2016) Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis. Oncogene 35 5388 PMID: 27109105

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Pathways for NSC 33994

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.