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Ruxolitinib phosphate

Cat. No. 7048 Submit a Review Datasheet / COA / SDS
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Description: Phosphate salt of Ruxolitinib (Cat. No. 7064); potent and selective JAK1/JAK2 inhibitor
Chemical Name: (3R)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile phosphate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Ruxolitinib phosphate

Ruxolitinib phosphate is a phosphate salt of Ruxolitinib (Cat. No. 7064). Potent and selective JAK1/JAK2 inhibitor; orally bioavailable.

Compound Libraries for Ruxolitinib phosphate

Ruxolitinib phosphate is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Ruxolitinib phosphate

M. Wt 404.37
Formula C17H18N6.H3O4P
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1092939-17-7
PubChem ID 25127112
InChI Key JFMWPOCYMYGEDM-XFULWGLBSA-N
Smiles OP(O)(O)=O.N#CC[C@@H](N1C=C(C2=C3C=CNC3=NC=N2)C=N1)C4CCCC4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ruxolitinib phosphate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.44 100
ethanol 4.04 10

Preparing Stock Solutions for Ruxolitinib phosphate

The following data is based on the product molecular weight 404.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.47 mL 12.36 mL 24.73 mL
5 mM 0.49 mL 2.47 mL 4.95 mL
10 mM 0.25 mL 1.24 mL 2.47 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets for Ruxolitinib phosphate

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for Ruxolitinib phosphate

References are publications that support the biological activity of the product.

Lin et al (2019) Enantioselective synthesis of Janus kinase inhibitor INCB018424 via an organocatalytic aza-Michael reaction. Org.Lett. 11 1999 PMID: 19385672

Quintás-Cardama et al (2010) Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood 113 3109 PMID: 20130243

If you know of a relevant reference for Ruxolitinib phosphate, please let us know.

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Keywords: Ruxolitinib phosphate, Ruxolitinib phosphate supplier, Potent, selective, JAK1/JAK2, inhibitors, inhibits, JAK1, JAK2, orally, bioavailable, active, in, vivo, JAK, Kinase, 7048, Tocris Bioscience

Citations for Ruxolitinib phosphate

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Pathways for Ruxolitinib phosphate

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.