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SMER 3

Cat. No. 4375 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Selective inhibitor of E3 ubiquitin ligase
Chemical Name: 9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (3)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for SMER 3

SMER 3 is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. Induces the expression of MET genes; blocks cell proliferation. Enhancer of rapamycin (Cat. No. 1292).

Compound Libraries for SMER 3

SMER 3 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for SMER 3

M. Wt 224.18
Formula C11H4N4O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 67200-34-4
PubChem ID 568763
InChI Key SFSSAKVWCKFRHE-UHFFFAOYSA-N
Smiles O=C4C2=NC1=NON=C1N=C2C3=CC=CC=C34

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SMER 3

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.81 75

Preparing Stock Solutions for SMER 3

The following data is based on the product molecular weight 224.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 5.95 mL 29.74 mL 59.48 mL
3.75 mM 1.19 mL 5.95 mL 11.9 mL
7.5 mM 0.59 mL 2.97 mL 5.95 mL
37.5 mM 0.12 mL 0.59 mL 1.19 mL

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References for SMER 3

References are publications that support the biological activity of the product.

Aghajanyy et al (2010) Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor. Nat.Biotechnol. 28 738 PMID: 20581845

If you know of a relevant reference for SMER 3, please let us know.

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Keywords: SMER 3, SMER 3 supplier, SMER3, ubiquitin, E3, ligase, inhibitors, inhibits, Ub, ligases, small-molecule, enhancers, rapamycin, SCF, family, Ubiquitin, Ligases, 4375, Tocris Bioscience

1 Citation for SMER 3

Citations are publications that use Tocris products. Selected citations for SMER 3 include:

Babu L et al (2017) Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads. BMC Pharmacol Toxicol 18 40 PMID: 28577368

Do you know of a great paper that uses SMER 3 from Tocris? Please let us know.

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Literature in this Area

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