Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewTAME hydrochloride
Description: Ubiquitin ligase APC/C inhibitor; promotes Cdc20 autoubiquitination
Chemical Name: N2-[(4-Methylphenyl)sulfonyl]-L-arginine methyl ester hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for TAME hydrochloride
TAME hydrochloride is a competitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C); promotes Cdc20 autoubiquitination. Inhibits cyclin proteolysis in mitotic Xenopus oocyte extracts (IC50 = 12 μM) and blocks cyclin degradation in interphase extract.
Technical Data for TAME hydrochloride
| M. Wt | 378.87 |
| Formula | C14H22N4O4S.HCl |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1784-03-8 |
| PubChem ID | 2723792 |
| InChI Key | JIQFFACVQXXHMY-YDALLXLXSA-N |
| Smiles | NC(NCCC[C@H](NS(C1=CC=C(C)C=C1)(=O)=O)C(OC)=O)=N.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TAME hydrochloride
References for TAME hydrochloride
References are publications that support the biological activity of the product.
Zeng et al (2010) Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell. 18 382 PMID: 20951947
Zeng & King (2012) An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nat.Chem.Biol. 8 383 PMID: 22366722
View Related Products by Target
View Related Products by Product Action
Keywords: TAME hydrochloride, TAME hydrochloride supplier, ubiquitin, ligase, anaphase-promoting, complex/cyclosome, APC, inhibits, inhibitors, competitive, mitotic, arrest, cyclin, stabilization, TAME, hydrochloride, HCl, Ubiquitin, E3, Ligases, Mitosis, 4506, Tocris Bioscience
1 Citation for TAME hydrochloride
Citations are publications that use Tocris products. Selected citations for TAME hydrochloride include:
Coles et al (2015) KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms. PLoS Genet 11 e1005525 PMID: 26439735
Reviews for TAME hydrochloride
There are currently no reviews for this product. Be the first to review TAME hydrochloride and earn rewards!
Have you used TAME hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
TPD and Induced Proximity Research Product GuideUpdated
This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Assays for Protein Degradation
- Induced Proximity Tools
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia