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Description: Dual-kinase inhibitor; inhibits CK2 and ERK8
Chemical Name: 2-(4,5,6,7-Tetrabromo-2-(dimethylamino)-1H-benzo[d]imidazol-1-yl)acetic acid
Purity: ≥98% (HPLC)
Biological Activity for TMCB
TMCB is a dual-kinase inhibitor; inhibits both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) (IC50 = 0.50 μM for both CK2 and ERK8). Displays selectivity for CK2 over protein kinases normally susceptible to CK2 inhibitors (Ki values are 0.25, 8.65, 11.90 and 15.25 μM for CK2, PIM1, DYRK1a and HIPK2 respectively).
Compound Libraries for TMCB
TMCB is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
Technical Data for TMCB
| M. Wt | 534.82 |
| Formula | C11H9Br4N3O2 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 905105-89-7 |
| PubChem ID | 46943415 |
| InChI Key | PHAOTASRLQMKBE-UHFFFAOYSA-N |
| Smiles | BrC1=C2C(N(CC(O)=O)C(N(C)C)=N2)=C(Br)C(Br)=C1Br |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TMCB
References for TMCB
References are publications that support the biological activity of the product.
Pagano et al (2008) The selectivity of inhibitors of protein kinase CK2: an update. Biochem.J. 415 353 PMID: 18588507
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Keywords: TMCB, TMCB supplier, casein, kinase, 2, ck2, extracellular-signal-regulated, 8, ERK8, dual, inhibitors, inhibits, Casein, Kinase, ERK, 3675, Tocris Bioscience
1 Citation for TMCB
Citations are publications that use Tocris products. Selected citations for TMCB include:
Schevzov et al (2015) Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments. Mol Biol Cell 26 2475 PMID: 25971798
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Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets