Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewTNP
Description: Inhibitor of IP6K; also inhibits IP3K
Chemical Name: N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-9H-Purine-2,6-diamine
Purity: ≥97% (HPLC)
Biological Activity for TNP
TNP is a reversible inositol hexakisphosphate kinase (IP6K) inhibitor (IC50 = 0.47 μM for inhibition of InsP7 formation). Also inhibits inositol 1,4,5-trisphosphate 3-kinase (IP3K) (IC50 = 10.2 μM). Binds to the ATP binding site of IP3K (Ki = 4.3 μM).
Technical Data for TNP
| M. Wt | 443.38 |
| Formula | C20H16F3N7O2 |
| Storage | Store at +4°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 519178-28-0 |
| PubChem ID | 16760513 |
| InChI Key | DDSBPUYZPWNNGH-UHFFFAOYSA-N |
| Smiles | O=[N+](C(C=C4)=CC=C4CNC1=C2C(NC=N2)=NC(NCC3=CC=CC(C(F)(F)F)=C3)=N1)[O-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for TNP
References for TNP
References are publications that support the biological activity of the product.
Padmanabhan et al (2009) Characterization of a selective inhibitor of inositol hexakisphosphate kinases. Use in defining biological roles and metabolic relationships of inositol pyrophosphates. J.Biol.Chem. 284 10571 PMID: 19208622
Chang et al (2002) Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase. Chembiochem 3 897 PMID: 12210991
View Related Products by Target
View Related Products by Product Action
Keywords: TNP, TNP supplier, TNP, inhibitors, inhibits, inositol, 1,4,5-triphosphate, 3-kinase, IP3K, hexakisphosphate, kinases, IP6K, lipids, Other, Kinases, Inositol, Lipids, 3946, Tocris Bioscience
1 Citation for TNP
Citations are publications that use Tocris products. Selected citations for TNP include:
Andrew M et al (2022) Acute adaptation of renal phosphate transporters in the murine kidney to oral phosphate intake requires multiple signals. Acta Physiol (Oxf) 235 e13815 PMID: 35334154
Reviews for TNP
There are currently no reviews for this product. Be the first to review TNP and earn rewards!
Have you used TNP?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image