XMU MP 1

Cat. No. 6482 5 Citations Submit a Review Datasheet / COA / SDS

Pricing	Availability		Qty

Description: Potent and selective MST1/2 inhibitor; orally bioavailable

Chemical Name: 4-[(6,10-Dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide

Purity: ≥98% (HPLC)

Datasheet

Citations (5)

Reviews

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for XMU MP 1

XMU MP 1 is a potent and selective ATP-competitive mammalian sterile 20-like kinase (MST) 1/2 inhibitor (IC₅₀ values are 38.1 and 71.1 nM for MST2 and MST1, respectively). Enhances activity of downstream YAP in vitro. Augments mouse intestinal repair and promotes liver repair and regeneration in a mouse model of acute and chronic liver injury. Orally bioavailable.

Licensing Information

Sold under license from Dana-Farber Cancer Institute.

Compound Libraries for XMU MP 1

XMU MP 1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for XMU MP 1

M. Wt	416.48
Formula	C₁₇H₁₆N₆O₃S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2061980-01-4
PubChem ID	121499143
InChI Key	YRDHKIFCGOZTGD-UHFFFAOYSA-N
Smiles	CN1C2=C(C(N(C3=CN=C(N=C13)NC4=CC=C(S(N)(=O)=O)C=C4)C)=O)SC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for XMU MP 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	41.65	100

Preparing Stock Solutions for XMU MP 1

The following data is based on the product molecular weight 416.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.4 mL	12.01 mL	24.01 mL
5 mM	0.48 mL	2.4 mL	4.8 mL
10 mM	0.24 mL	1.2 mL	2.4 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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Product Datasheets for XMU MP 1

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for XMU MP 1

References are publications that support the biological activity of the product.

Fan et al (2016) Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration. Sci.Transl.Med. 8 352 PMID: 27535619

Ray et al (2016) Therapy: Targeting liver tissue repair and regeneration. Nat.Rev.Gastroenterol.Hepatol. 13 559 PMID: 27605063

Crunkhorn et al (2016) Regenerative medicine: Inhibiting Hippo repairs tissue. Nat.Rev.Drug Discov. 15 678 PMID: 27681796

If you know of a relevant reference for XMU MP 1, please let us know.

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