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ZM 39923 hydrochloride

Cat. No. 1367 3 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent, selective JAK3 inhibitor
Chemical Name: 3-benzylisopropylamino-1-naphthalen-2-yl-propan-1-one hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for ZM 39923 hydrochloride

ZM 39923 hydrochloride is a potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3). pIC50 values are 7.1, 5.6, 4.4, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Breaks down in neutral buffer (t½ = 36 mins, pH 7.43, 25°C) to form ZM 449829 (Cat. No. 1366).

Licensing Information

Sold with the permission of AstraZeneca Ltd.

Compound Libraries for ZM 39923 hydrochloride

ZM 39923 hydrochloride is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for ZM 39923 hydrochloride

M. Wt 367.92
Formula C23H25NO.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 1021868-92-7
PubChem ID 176406
InChI Key NJTUORMLOPXPBY-UHFFFAOYSA-N
Smiles Cl.CC(C)N(CCC(=O)C1=CC=C2C=CC=CC2=C1)CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ZM 39923 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.79 100

Preparing Stock Solutions for ZM 39923 hydrochloride

The following data is based on the product molecular weight 367.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.72 mL 13.59 mL 27.18 mL
5 mM 0.54 mL 2.72 mL 5.44 mL
10 mM 0.27 mL 1.36 mL 2.72 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets for ZM 39923 hydrochloride

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for ZM 39923 hydrochloride

References are publications that support the biological activity of the product.

Brown et al (2000) Naphthyl ketones: a new class of janus kinase 3 inhibitors. Bioorg.Med.Chem.Lett. 10 575 PMID: 10741557

If you know of a relevant reference for ZM 39923 hydrochloride, please let us know.

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3 Citations for ZM 39923 hydrochloride

Citations are publications that use Tocris products. Selected citations for ZM 39923 hydrochloride include:

Rogers and Gahring (2015) Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways. Autophagy 10 e0143319 PMID: 26619345

Vidro-Kotchan et al (2011) NBHA reduces acrolein-induced changes in ARPE-19 cells: possible involvement of TGFβ. Curr Eye Res 36 370 PMID: 21309688

Schaertl et al (2010) A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors. J Biomol Screen 15 478 PMID: 20395409

Do you know of a great paper that uses ZM 39923 hydrochloride from Tocris? Please let us know.

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Pathways for ZM 39923 hydrochloride

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.