3-Methyladenine

Cat. No. 3977 10 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Class III PI 3-kinase inhibitor; also inhibits autophagy

别名： 3-MA

化学名： 3-Methyl-3H-purin-6-amine

纯度： ≥99% (HPLC)

引用文献 (10)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for 3-Methyladenine

3-Methyladenine is an inhibitor of class III phosphatidylinositol 3-kinase (PI 3-kinase); also inhibits the autophagic sequestration of cell proteins in rat hepatocytes. Blocks apoptosis in cerebellar granule cells (CGCs) following serum and potassium deprivation.

化合物库 for 3-Methyladenine

3-Methyladenine is also offered as part of the Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for 3-Methyladenine

分子量	149.15
公式	C₆H₇N₅
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	5142-23-4
PubChem ID	1673
InChI Key	FSASIHFSFGAIJM-UHFFFAOYSA-N
Smiles	NC(N=CN2C)=C1C2=NC=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for 3-Methyladenine

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	2.98	20

制备储备液 for 3-Methyladenine

以下数据基于产品分子量 149.15。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	33.52 mL	167.62 mL	335.23 mL
1 mM	6.7 mL	33.52 mL	67.05 mL
2 mM	3.35 mL	16.76 mL	33.52 mL
10 mM	0.67 mL	3.35 mL	6.7 mL

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产品说明书 for 3-Methyladenine

分析证书/产品说明书

化学品安全技术说明书

参考文献 for 3-Methyladenine

参考文献是支持产品生物活性的出版物。

Blommaart et al (1997) The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur.J.Biochem. 243 240 PMID: 9030745

Canu et al (2005) Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells. J.Neurochem. 92 1228 PMID: 15715672

Seglen and Gordon (1982) 3-methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc.Natl.Acad.Sci.U.S.A. 79 1889 PMID: 6952238

If you know of a relevant reference for 3-Methyladenine, please let us know.

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关键词: 3-Methyladenine, 3-Methyladenine supplier, pi, 3-kinase, phosphatidylinositol, 3, kinase, inhibitors, inhibits, autophagy, 3-MA, pi3k, vps34, PIK3C3, PI, 3-Kinase, Inositol, Lipids, Other, Apoptosis, Autophagy, 3977, Tocris Bioscience