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说明： Cdc20 inhibitor; inhibits Cdc20-substrate interaction
化学名： 3-(2-Methyl-5-nitroimidazol-1-yl)-N-(2,2,2-trichloro-1-phenylaminoethyl)propionamide
纯度： ≥98% (HPLC)
生物活性 for Apcin
Apcin is a Cdc20 inhibitor; inhibits Cdc20-substrate interaction. Blocks substrate-mediated Cdc20 loading onto the anaphase-promoting complex (APC). Inhibits APC-dependent ubiquitylation. Prolongs mitotic duration in RPE1 cells in combination with proTAME (prodrug of TAME (Cat.No. 4506)) in vitro.
技术数据 for Apcin
| 分子量 | 438.65 |
| 公式 | C13H14Cl3N7O4 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 300815-04-7 |
| PubChem ID | 2830389 |
| InChI Key | ZEXHXVOGJFGTRX-UHFFFAOYSA-N |
| Smiles | CC1=NC=C([N+]([O-])=O)N1CCOC(NC(C(Cl)(Cl)Cl)NC2=NC=CC=N2)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Apcin
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 43.87 | 100 |
制备储备液 for Apcin
以下数据基于产品分子量 438.65。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.28 mL | 11.4 mL | 22.8 mL |
| 5 mM | 0.46 mL | 2.28 mL | 4.56 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.28 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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产品说明书 for Apcin
参考文献 for Apcin
参考文献是支持产品生物活性的出版物。
Sackton et al (2014) Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. Nature 514 646 PMID: 25156254
Wang et al (2015) Targeting Cdc20 as a novel cancer therapeutic strategy. Pharmacol.Ther. 151 141 PMID: 25850036
If you know of a relevant reference for Apcin, please let us know.
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关键词: Apcin, Apcin supplier, Cdc20, inhibitors, inhibits, APC, anaphase-promoting, complex, ubiquitin, ubiquitination, ligases, E3, Ubiquitin, Ligases, Mitosis, 5747, Tocris Bioscience
5 篇 Apcin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Apcin 的部分引用包括：
Shabaz et al (2020) Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit. Elife 9 PMID: 32869743
Afonso et al (2019) Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk. Elife 8 PMID: 31424385
Greg et al (2019) Tetraploidy causes chromosomal instability in acentriolar mouse embryos. Nat Commun 10 4834 PMID: 31645568
Venturina et al (2023) AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation. Life Sci Alliance 6 PMID: 36797043
Lin et al (2023) Kinetochore deterioration concommitant with centromere weakening during aging in mouse oocyte meiosis-I. FASEB J 37 e22922 PMID: 37078553
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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