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Submit ReviewCHIR 99021 in solution 最新
说明： Sterile-filtered 10 mM solution of CHIR 99021 pre-dissolved in DMSO
化学名： 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
纯度： ≥97% (HPLC)
生物活性 for CHIR 99021 in solution
CHIR 99021 in solution is a convenient and ready-to-use 10 mM sterile-filtered solution of CHIR 99021 (Cat. No. 4423) pre-dissolved in DMSO. A potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3) (IC50 values are 6.7 and 10 nM for GSK-3β and GSK-3α respectively). Acts as Wnt activator. In combination with the irreversible inhibitor of LSD1, Tranylcypromine (Cat. No. 3852), CHIR 99021 enables reprogramming of mouse embryonic fibroblasts into iPSCs. Enhances mouse and human ESC self-renewal when used in combination with PD 0325901 (Cat. No. 4192); promotes differentiation of hPSCs in cardiomyocytes and allows formation of extended pluripotent stem (EPS) cells in combination with (S)-(+)-Dimethindene maleate (Cat. No. 1425), Minocycline (Cat. No. 3268) and human leukemia inhibitory factor.
CHIR 99021 synthesized to cGMP guidelines also available.
技术数据 for CHIR 99021 in solution
| 分子量 | 465.34 |
| 公式 | C22H18Cl2N8 |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 252917-06-9 |
| PubChem ID | 9956119 |
| InChI Key | AQGNHMOJWBZFQQ-UHFFFAOYSA-N |
| Smiles | ClC(C=C1Cl)=CC=C1C2=NC(NCCNC3=CC=C(C#N)C=N3)=NC=C2C4=NC=C(C)N4 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for CHIR 99021 in solution
参考文献 for CHIR 99021 in solution
参考文献是支持产品生物活性的出版物。
Ye et al (2012) Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embyronic stem cells from refractory mouse strains. PLoS One 7 e35892 PMID: 22540008
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
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