Cucurbitacin I

Cat. No. 1571 8 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective inhibitor of STAT3/JAK2 signaling

别名： Elatericin B,JSI 124

化学名： (9β,10α,16α,23E)-2,16,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione

纯度： ≥95% (HPLC)

引用文献 (8)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Cucurbitacin I

Cucurbitacin I is a selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.

技术数据 for Cucurbitacin I

分子量	514.65
公式	C₃₀H₄₂O₇
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	2222-07-3
PubChem ID	5281321
InChI Key	NISPVUDLMHQFRQ-MKIKIEMVSA-N
Smiles	OC(C)(C)/C=C/C([C@@](O)(C)[C@@]3([H])[C@H](O)C[C@@]([C@@](C)3C4)(C)[C@]2([H])CC=C1C(C)(C)C(C(O)=C[C@]([H])1[C@@](C)2C4=O)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Cucurbitacin I

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	5.15	10

制备储备液 for Cucurbitacin I

以下数据基于产品分子量 514.65。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.1 mM	19.43 mL	97.15 mL	194.31 mL
0.5 mM	3.89 mL	19.43 mL	38.86 mL
1 mM	1.94 mL	9.72 mL	19.43 mL
5 mM	0.39 mL	1.94 mL	3.89 mL

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产品说明书 for Cucurbitacin I

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Cucurbitacin I

参考文献是支持产品生物活性的出版物。

Blaskovich et al (2003) Discovery of JSI-124 (cucurbitacin I), a selective janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res. 63 1270 PMID: 12649187

Nefedova et al (2005) Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway. Cancer Res. 65 9525 PMID: 16230418

Dziennis et al (2007) Role of signal transducer and activator of transcription-3 in OE-mediated neuroprotection. J.Neurosci. 27 7268 PMID: 17611279

If you know of a relevant reference for Cucurbitacin I, please let us know.

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关键词: Cucurbitacin I, Cucurbitacin I supplier, Selective, inhibitors, inhibits, STAT3/JAK2, signaling, signalling, Janus, Activated, Kinase, JAK, Kinases, Signal, Transducers, activators, Transcription, STAT, CucurbitacinI, ElatericinB, JSI124, Elatericin, B, JSI, 124, 1571, Tocris Bioscience

8 篇 Cucurbitacin I 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Cucurbitacin I 的部分引用包括：

Martin-Gallausiaux et al (2019) Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells. Front Immunol 9 2838 PMID: 30619249

Hamilton et al (2011) Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells. Mol Cancer Res 9 1718 PMID: 21994466

Rogers and Gahring (2015) Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways. Cell Rep 10 e0143319 PMID: 26619345

Wan et al (2014) Retinal injury, growth factors, and cytokines converge on β-catenin and pStat3 signaling to stimulate retina regeneration. J Neurosci 9 285 PMID: 25263555

Stechishin et al (2013) On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells. Neuro Oncol 15 198 PMID: 23262510

Tiffon et al (2011) The histone deacetylase inhibitors vorin. and romid. downmodulate IL-10 expression in cutaneous T-cell lymphoma cells. Br J Pharmacol 162 1590 PMID: 21198545

Bonifazi et al (2009) Balancing inflammation and tolerance in vivo through dendritic cells by the commensal Candida albicans. Mucosal Immunol 2 362 PMID: 19421183

Zhu et al (2016) Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis. Oncogene 35 5388 PMID: 27109105

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Pathways for Cucurbitacin I

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.