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Heclin

Cat. No. 5433 4 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： HECT E3 ubiquitin ligase inhibitor
化学名： N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide
纯度： ≥98% (HPLC)
说明书
引用文献 (4)
评论
文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Heclin

Heclin is a HECT E3 ubiquitin ligase inhibitor; inhibits Nedd4, Smurf2 and WWP1 (IC50 values are 6.3, 6.8 and 6.9 μM respectively). Selective for HECT-mediated over RING-mediated ubiquitination.

化合物库 for Heclin

Heclin is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Heclin

分子量 283.32
公式 C17H17NO3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 890605-54-6
PubChem ID 7464118
InChI Key SPTWXRJNCFIDRQ-ZHACJKMWSA-N
Smiles CC(C1=CC=C(NC(/C=C/C2=CC=C(CC)O2)=O)C=C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Heclin

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 28.33 100
ethanol 14.17 50

制备储备液 for Heclin

以下数据基于产品分子量 283.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.53 mL 17.65 mL 35.3 mL
5 mM 0.71 mL 3.53 mL 7.06 mL
10 mM 0.35 mL 1.76 mL 3.53 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for Heclin

参考文献是支持产品生物活性的出版物。

Mund et al (2014) Peptide and small molecule inhibitors of HECT-type ubiquitin ligases. Proc.Natl.Acad.Sci.U.S.A. 111 16736 PMID: 25385595

If you know of a relevant reference for Heclin, please let us know.

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关键词: Heclin, Heclin supplier, E6-AP, carboxyl, terminus, HECT, E3, ubiquitin, ubiquitination, inhibitors, inhibits, inhibts, NAMs, negative, allosteric, modulators, Ubiquitin, Ligases, 5433, Tocris Bioscience

4 篇 Heclin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Heclin 的部分引用包括：

Yang et al (2020) Natural cardenolides suppress coronaviral replication by downregulating JAK1 via a Na+/K+-ATPase independent proteolysise Biochem Pharmacol 180 PMID: 32592721

Cheng-Wei et al (2022) Tyrphostin AG1024 Suppresses Coronaviral Replication by Downregulating JAK1 via an IR/IGF-1R Independent Proteolysis Mediated by Ndfip1/2_NEDD4-like E3 Ligase Itch. Pharmaceuticals (Basel) 15 PMID: 35215353

Yingxian et al (2020) The E3 ubiquitin ligase Smurf2 regulates PARP1 stability to alleviate oxidative stress-induced injury in human umbilical vein endothelial cells. J Cell Mol Med 24 4600-4611 PMID: 32167680

Saskia C et al (2020) Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes. Life Sci Alliance 3 PMID: 33097557

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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