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Submit ReviewNSC 624206
说明： Ubiquitin-activating enzyme (E1) inhibitor
化学名： N-[2-[[(4-Chlorophenyl)methyl]dithio]ethyl]-1-decanamine hydrochloride
纯度： ≥98% (HPLC)
生物活性 for NSC 624206
NSC 624206 is an ubiquitin-activating enzyme (E1) inhibitor; prevents tumour suppressor protein p27 ubiquitination in vitro. Blocks the ubiquitin-thioester formation step of the E1 activation reaction, but displays no effect on ubiquitin adenylation.
技术数据 for NSC 624206
| 分子量 | 410.51 |
| 公式 | C19H32ClNS2.HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 13116-77-3 |
| PubChem ID | 361263 |
| InChI Key | JQHUAYXPNPTQRO-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(CSSCCNCCCCCCCCCC)C=C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for NSC 624206
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 20.53 | 50 | |
| ethanol | 8.21 | 20 |
制备储备液 for NSC 624206
以下数据基于产品分子量 410.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.87 mL | 24.36 mL | 48.72 mL |
| 2.5 mM | 0.97 mL | 4.87 mL | 9.74 mL |
| 5 mM | 0.49 mL | 2.44 mL | 4.87 mL |
| 25 mM | 0.1 mL | 0.49 mL | 0.97 mL |
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产品说明书 for NSC 624206
参考文献 for NSC 624206
参考文献是支持产品生物活性的出版物。
Ungermannova et al (2012) Identification and mechanistic studies of a novel ubiquitin E1 inhibitor. J.Biomol.Screen. 17 421 PMID: 22274912
If you know of a relevant reference for NSC 624206, please let us know.
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关键词: NSC 624206, NSC 624206 supplier, NSC624206, tumour, suppressor, protein, p27, ubiquitination, thioesterformation, adenylation, ubiquitin-activating, enzymes, E1, inhibitors, inhibits, Ubiquitin-activating, Enzyme, Post-translational, Modifications, 4993, Tocris Bioscience
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