PI 103 hydrochloride

Cat. No. 2930 10 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Inhibitor of PI 3-kinase, mTOR and DNA-PK

化学名： 3-[4-(4-Morpholinylpyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol hydrochloride

纯度： ≥98% (HPLC)

引用文献 (10)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PI 103 hydrochloride

PI 103 hydrochloride is an inhibitor of DNA-PK, PI 3-kinase (p110α) and mTOR (IC₅₀ values are 2, 8, 20, 26, 48, 83, 88, 150, 850, 920, ~ 1000 and 2300 nM for DNA-PK, p110α, mTORC1, PI 3-KC2β, p110δ, mTORC2, p110β, p110γ, ATR, ATM, PI 3-KC2α and hsVPS34 respectively). Inhibits growth of human tumor xenografts in mice in vivo. Induces autophagosome formation in glioma cells.

化合物库 for PI 103 hydrochloride

PI 103 hydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for PI 103 hydrochloride

分子量	384.82
公式	C₁₉H₁₆N₄O₃.HCl
储存	Desiccate at +4°C
纯度	≥98% (HPLC)
CAS Number	371935-79-4
PubChem ID	16739368
InChI Key	XSQMYBFFYPTMFE-UHFFFAOYSA-N
Smiles	OC1=CC(C(N=C4N5CCOCC5)=NC3=C4OC2=NC=CC=C23)=CC=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PI 103 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	7.7	20

制备储备液 for PI 103 hydrochloride

以下数据基于产品分子量 384.82。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	12.99 mL	64.97 mL	129.93 mL
1 mM	2.6 mL	12.99 mL	25.99 mL
2 mM	1.3 mL	6.5 mL	12.99 mL
10 mM	0.26 mL	1.3 mL	2.6 mL

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产品说明书 for PI 103 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PI 103 hydrochloride

参考文献是支持产品生物活性的出版物。

Fan et al (2006) A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer cell 9 341 PMID: 16697955

Knight et al (2006) A pharmacological map of the PI3-K family defines a role for p110α in Ins signaling. Cell 125 733 PMID: 16647110

Raynaud et al (2007) Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositol 3-kinase. Cancer Res. 67 5840 PMID: 17575152

Fan et al (2010) Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci.Signal. 3 ra81 PMID: 21062993

If you know of a relevant reference for PI 103 hydrochloride, please let us know.

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