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说明： Ubiquitin-activating enzyme (E1) inhibitor
化学名： 1-(3-Chloro-4-fluorophenyl)-4-[(5-nitro-2-furanyl)methylene]-3,5-pyrazolidinedione
纯度： ≥98% (HPLC)
生物活性 for PYZD 4409
PYZD 4409 is an ubiquitin-activating enzyme (E1) inhibitor. Blocks degradation of p53 and cyclin D3. Inhibits NF-κB activation and induces cell death associated with ER stress. Displays antitumor effects in a mouse model of leukemia.
技术数据 for PYZD 4409
| 分子量 | 351.67 |
| 公式 | C14H7ClFN3O5 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 423148-78-1 |
| PubChem ID | 60111983 |
| InChI Key | MSYMKEYWUWVZQY-TWGQIWQCSA-N |
| Smiles | FC(C=C3)=C(Cl)C=C3N(C(/C1=C\C2=CC=C([N+]([O-])=O)O2)=O)NC1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for PYZD 4409
参考文献 for PYZD 4409
参考文献是支持产品生物活性的出版物。
Xu et al (2010) The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. Blood 115 2251 PMID: 20075161
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关键词: PYZD 4409, PYZD 4409 supplier, PYZD4409, ubiquitin-activating, enzyme, E1, inhibitors, inhibits, ubiquitylation, ubiquitin, Ubiquitin-activating, Enzyme, Post-translational, Modifications, 4994, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Autophagy Scientific Review
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Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.