Ruxolitinib phosphate

Cat. No. 7048 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Phosphate salt of Ruxolitinib (Cat. No. 7064); potent and selective JAK1/JAK2 inhibitor

化学名： (3R)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile phosphate

纯度： ≥98% (HPLC)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Ruxolitinib phosphate

Ruxolitinib phosphate is a phosphate salt of Ruxolitinib (Cat. No. 7064). Potent and selective JAK1/JAK2 inhibitor; orally bioavailable.

化合物库 for Ruxolitinib phosphate

Ruxolitinib phosphate is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Ruxolitinib phosphate

分子量	404.37
公式	C₁₇H₁₈N₆.H₃O₄P
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1092939-17-7
PubChem ID	25127112
InChI Key	JFMWPOCYMYGEDM-XFULWGLBSA-N
Smiles	OP(O)(O)=O.N#CC[C@@H](N1C=C(C2=C3C=CNC3=NC=N2)C=N1)C4CCCC4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ruxolitinib phosphate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	40.44	100
	ethanol	4.04	10

制备储备液 for Ruxolitinib phosphate

以下数据基于产品分子量 404.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.47 mL	12.36 mL	24.73 mL
5 mM	0.49 mL	2.47 mL	4.95 mL
10 mM	0.25 mL	1.24 mL	2.47 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

Molarity Calculator

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产品说明书 for Ruxolitinib phosphate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Ruxolitinib phosphate

参考文献是支持产品生物活性的出版物。

Lin et al (2019) Enantioselective synthesis of Janus kinase inhibitor INCB018424 via an organocatalytic aza-Michael reaction. Org.Lett. 11 1999 PMID: 19385672

Quintás-Cardama et al (2010) Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood 113 3109 PMID: 20130243

If you know of a relevant reference for Ruxolitinib phosphate, please let us know.

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