SB 747651A dihydrochloride

Cat. No. 4630 8 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent MSK1 inhibitor; also inhibits other AGC group kinases

化学名： 2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-4-piperidinyl-1H-imidazo[4,5-c]pyridine-7-methanamine dihydrochloride

纯度： ≥98% (HPLC)

引用文献 (8)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SB 747651A dihydrochloride

SB 747651A dihydrochloride is a potent, ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor (IC₅₀ = 11 nM in an in vitro kinase assay); targets the N-terminal kinase domain. Inhibits MSK1, MSK2, PKA, PKB, RSK and p70^S6K activity in cells. Blocks IL-10 production in macrophages.

许可信息

Sold with the permission of GlaxoSmithKline.

化合物库 for SB 747651A dihydrochloride

SB 747651A dihydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for SB 747651A dihydrochloride

分子量	415.32
公式	C₁₆H₂₂N₈O.2HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	1781882-72-1
PubChem ID	90488958
InChI Key	NRRCQHARLPNLHJ-UHFFFAOYSA-N
Smiles	NC1=NON=C1C3=NC2=CN=CC(CNC4CCNCC4)=C2N3CC.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SB 747651A dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	20.77	50
	DMSO	20.77	50

制备储备液 for SB 747651A dihydrochloride

以下数据基于产品分子量 415.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	4.82 mL	24.08 mL	48.16 mL
2.5 mM	0.96 mL	4.82 mL	9.63 mL
5 mM	0.48 mL	2.41 mL	4.82 mL
25 mM	0.1 mL	0.48 mL	0.96 mL

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产品说明书 for SB 747651A dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SB 747651A dihydrochloride

参考文献是支持产品生物活性的出版物。

Bamford et al (2005) (1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: a novel class of potent MSK-1-inhibitors. Bioorg.Med.Chem.Lett. 15 3402 PMID: 15950465

Bamford et al (2005) (1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: further optimisation as highly potent and selective MSK-1-inhibitors. Bioorg.Med.Chem.Lett. 15 3407 PMID: 15955699

Naqvi et al (2012) Characterization of the cellular action of the MSK inhibitor SB-747651A. Biochem.J. 441 347 PMID: 21970321

If you know of a relevant reference for SB 747651A dihydrochloride, please let us know.

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