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SMER 3

Cat. No. 4375 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective inhibitor of E3 ubiquitin ligase
化学名： 9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SMER 3

SMER 3 is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. Induces the expression of MET genes; blocks cell proliferation. Enhancer of rapamycin (Cat. No. 1292).

化合物库 for SMER 3

SMER 3 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for SMER 3

分子量 224.18
公式 C11H4N4O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 67200-34-4
PubChem ID 568763
InChI Key SFSSAKVWCKFRHE-UHFFFAOYSA-N
Smiles O=C4C2=NC1=NON=C1N=C2C3=CC=CC=C34

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SMER 3

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 16.81 75

制备储备液 for SMER 3

以下数据基于产品分子量 224.18。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.75 mM 5.95 mL 29.74 mL 59.48 mL
3.75 mM 1.19 mL 5.95 mL 11.9 mL
7.5 mM 0.59 mL 2.97 mL 5.95 mL
37.5 mM 0.12 mL 0.59 mL 1.19 mL

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参考文献 for SMER 3

参考文献是支持产品生物活性的出版物。

Aghajanyy et al (2010) Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor. Nat.Biotechnol. 28 738 PMID: 20581845

If you know of a relevant reference for SMER 3, please let us know.

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关键词: SMER 3, SMER 3 supplier, SMER3, ubiquitin, E3, ligase, inhibitors, inhibits, Ub, ligases, small-molecule, enhancers, rapamycin, SCF, family, Ubiquitin, Ligases, 4375, Tocris Bioscience

1 篇 SMER 3 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SMER 3 的部分引用包括：

Babu L et al (2017) Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads. BMC Pharmacol Toxicol 18 40 PMID: 28577368

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该领域的文献

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Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia