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TCS 21311

Cat. No. 4221 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4221 has been discontinued.

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说明： Potent JAK3 inhibitor. Also inhibits GSK-3β and PKC
别名： NIBR3049
化学名： 3-[5-[4-(2-Hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
纯度： ≥98% (HPLC)
说明书
引用文献
评论
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for TCS 21311

TCS 21311 is a potent JAK3 inhibitor (IC50 = 8 nM). Selective for JAK3 over JAK1, JAK2 and TYK2 (IC50 values are 1017, 2550 and 8055 nM respectively). Also inhibits GSK-3β, PKCα and PKCθ (IC50 values are 3, 13 and 68 nM respectively).

化合物库 for TCS 21311

TCS 21311 is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for TCS 21311

分子量 526.51
公式 C27H25F3N4O4
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 1260181-14-3
PubChem ID 50925411
InChI Key CLGRAWDGLMENOD-UHFFFAOYSA-N
Smiles O=C(N1)C(C3=CNC4=C3C=CC=C4)=C(C2=C(C(F)(F)F)C=CC(N5CCN(C(C(O)(C)C)=O)CC5)=C2)C1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for TCS 21311

参考文献是支持产品生物活性的出版物。

Thoma et al (2010) Identification of a potent Janus kinase 3 inhibitor with high selectivity within the Janus kinase family. J.Med.Chem. 54 284 PMID: 21155605

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关键词: TCS 21311, TCS 21311 supplier, TCS21311, janus, kinases, jaks, jak3, inhibitors, inhibits, selective, potent, NIBR3049, JAK, Protein, Kinase, C, Glycogen, Synthase, 3, 4221, Tocris Bioscience

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Pathways for TCS 21311

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.