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TMCB

Cat. No. 3675 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3675 has been discontinued.

View all Casein Kinase 2 products.
说明： Dual-kinase inhibitor; inhibits CK2 and ERK8
化学名： 2-(4,5,6,7-Tetrabromo-2-(dimethylamino)-1H-benzo[d]imidazol-1-yl)acetic acid
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for TMCB

TMCB is a dual-kinase inhibitor; inhibits both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) (IC50 = 0.50 μM for both CK2 and ERK8). Displays selectivity for CK2 over protein kinases normally susceptible to CK2 inhibitors (Ki values are 0.25, 8.65, 11.90 and 15.25 μM for CK2, PIM1, DYRK1a and HIPK2 respectively).

化合物库 for TMCB

TMCB is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for TMCB

分子量 534.82
公式 C11H9Br4N3O2
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 905105-89-7
PubChem ID 46943415
InChI Key PHAOTASRLQMKBE-UHFFFAOYSA-N
Smiles BrC1=C2C(N(CC(O)=O)C(N(C)C)=N2)=C(Br)C(Br)=C1Br

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for TMCB

参考文献是支持产品生物活性的出版物。

Pagano et al (2008) The selectivity of inhibitors of protein kinase CK2: an update. Biochem.J. 415 353 PMID: 18588507

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关键词: TMCB, TMCB supplier, casein, kinase, 2, ck2, extracellular-signal-regulated, 8, ERK8, dual, inhibitors, inhibits, Casein, Kinase, ERK, 3675, Tocris Bioscience

1 篇 TMCB 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TMCB 的部分引用包括：

Schevzov et al (2015) Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments. Mol Biol Cell 26 2475 PMID: 25971798

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