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WH-4-023

Cat. No. 5413 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective Lck and Src inhibitor; also inhibits SIK
别名： KIN112
化学名： 2,6-Dimethylphenyl-N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]carbamate
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for WH-4-023

WH-4-023 is a potent and selective Lck and Src inhibitor (IC50 values are 2 and 6 nM respectively). Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases. Supports self-renewal of naive hESCs in combination with PD 0325901, CHIR 99021 and SB 590885.

External Portal Information for WH-4-023

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of WH-4-023 is reviewed on the chemical probes website.

化合物库 for WH-4-023

WH-4-023 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for WH-4-023

分子量 568.67
公式 C32H36N6O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 837422-57-8
PubChem ID 11844351
InChI Key NBTNHSGBRGTFJS-UHFFFAOYSA-N
Smiles O=C(OC5=C(C)C=CC=C5C)N(C4=CC=C(OC)C=C4OC)C1=NC(NC(C=C3)=CC=C3N2CCN(C)CC2)=NC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for WH-4-023

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 56.87 100

制备储备液 for WH-4-023

以下数据基于产品分子量 568.67。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.76 mL 8.79 mL 17.58 mL
5 mM 0.35 mL 1.76 mL 3.52 mL
10 mM 0.18 mL 0.88 mL 1.76 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

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产品说明书 for WH-4-023

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for WH-4-023

参考文献是支持产品生物活性的出版物。

Theunissen et al (2014) Systematic identification of culture conditions for induction and maintenance of naive human pluripotency. Cell Stem Cell 15 471 PMID: 25090446

Clark et al (2012) Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc.Natl.Acad.Sci.U.S.A. 109 16986 PMID: 23033494

Martin et al (2006) Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity. J.Med.Chem. 49 4981 PMID: 16884310

If you know of a relevant reference for WH-4-023, please let us know.

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关键词: WH-4-023, WH-4-023 supplier, Potent, selective, Lck, Src, inhibitors, inhibits, self-renewal, ESC, lymphocyte, specific, kinase, salt, inducible, SIK, KIN112, Kinases, Other, Stem, Cell, Proliferation, 5413, Tocris Bioscience

3 篇 WH-4-023 的引用文献

引用文献是使用了 Tocris 产品的出版物。 WH-4-023 的部分引用包括：

Rongfeng et al (2023) Species origin of exogenous transcription factors affects the activation of endogenous pluripotency markers and signaling pathways of porcine induced pluripotent stem cells. Front Cell Dev Biol 11 1196273 PMID: 37152293

Shahbazi et al (2017) Pluripotent state transitions coordinate morphogenesis in mouse and human embryos. Nature 552 239 PMID: 29186120

Gao et al (2019) Establishment of porcine and human expanded potential stem cells. Nat Cell Biol 21 687 PMID: 31160711

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