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WS 383

Cat. No. 7055 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent, selective and reversible DCN1-UBC12 interaction inhibitor
化学名： 5-[[2-[[(4-Chlorophenyl)methyl]thio]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]thio]-N,N-dimethyl-1H-tetrazole-1-ethanamine hydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for WS 383

WS 383 is a potent and reversible DCN1-UBC12 interaction inhibitor (IC50 = 11 nM). The compound displays selectivity for DCN1-UBC12 over inhibition of a panel of kinases. including Bruton's tyrosine kinase (BTK), cyclin-dependent kinases (CDKs) and epidermal growth factor receptor (EGFR). In vitro, WS 383 selectively inhibits cullin-3 neddylation over other cullins, and induces accumulation of p21, p27 and NRF2.

化合物库 for WS 383

WS 383 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for WS 383

分子量 498.45
公式 C18H20ClN9S2.HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2247544-02-9
PubChem ID 138319703
InChI Key LJZUAAKUJAXXHQ-UHFFFAOYSA-N
Smiles CN(CCN1N=NN=C1SC2=CC(C)=NC3=NC(SCC4=CC=C(C=C4)Cl)=NN23)C.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for WS 383

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 49.84 100

制备储备液 for WS 383

以下数据基于产品分子量 498.45。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.01 mL 10.03 mL 20.06 mL
5 mM 0.4 mL 2.01 mL 4.01 mL
10 mM 0.2 mL 1 mL 2.01 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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参考文献 for WS 383

参考文献是支持产品生物活性的出版物。

Wang et al (2019) Development of highly potent, selective, and cellular active triazolo[1,5- a]pyrimidine-based inhibitors targeting the DCN1-UBC12 protein-protein interaction. J.Med.Chem. 62 2772 PMID: 30803229

If you know of a relevant reference for WS 383, please let us know.

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关键词: WS 383, WS 383 supplier, WS383, ubiquitin, E3, E2, ligase, interaction, inhibitor, inhibits, protein-protein, Cul3/1, neddylation, CRL, cullin-RING, ligases, Ubiquitin, Ligases, Ubiquitin/Ubl, Conjugating, Enzymes, 7055, Tocris Bioscience

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