XMU MP 1

Pricing Availability   Qty
说明: Potent and selective MST1/2 inhibitor; orally bioavailable
化学名: 4-[(6,10-Dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide
纯度: ≥98% (HPLC)
说明书
引用文献 (5)
评论

生物活性 for XMU MP 1

XMU MP 1 is a potent and selective ATP-competitive mammalian sterile 20-like kinase (MST) 1/2 inhibitor (IC50 values are 38.1 and 71.1 nM for MST2 and MST1, respectively). Enhances activity of downstream YAP in vitro. Augments mouse intestinal repair and promotes liver repair and regeneration in a mouse model of acute and chronic liver injury. Orally bioavailable.

许可信息

Sold under license from Dana-Farber Cancer Institute.

化合物库 for XMU MP 1

XMU MP 1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for XMU MP 1

分子量 416.48
公式 C17H16N6O3S2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2061980-01-4
PubChem ID 121499143
InChI Key YRDHKIFCGOZTGD-UHFFFAOYSA-N
Smiles CN1C2=C(C(N(C3=CN=C(N=C13)NC4=CC=C(S(N)(=O)=O)C=C4)C)=O)SC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for XMU MP 1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 41.65 100

制备储备液 for XMU MP 1

以下数据基于产品分子量 416.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.4 mL 12.01 mL 24.01 mL
5 mM 0.48 mL 2.4 mL 4.8 mL
10 mM 0.24 mL 1.2 mL 2.4 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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产品说明书 for XMU MP 1

分析证书/产品说明书
选择另一批次:

参考文献 for XMU MP 1

参考文献是支持产品生物活性的出版物。

Fan et al (2016) Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration. Sci.Transl.Med. 8 352 PMID: 27535619

Ray et al (2016) Therapy: Targeting liver tissue repair and regeneration. Nat.Rev.Gastroenterol.Hepatol. 13 559 PMID: 27605063

Crunkhorn et al (2016) Regenerative medicine: Inhibiting Hippo repairs tissue. Nat.Rev.Drug Discov. 15 678 PMID: 27681796


If you know of a relevant reference for XMU MP 1, please let us know.

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关键词: XMU MP 1, XMU MP 1 supplier, XMUMP1, potent, selective, MST1, MST2, Inhibitors, inhibits, tissue, regeneration, liver, repair, orally, bioavailable, mammalian, sterile, 20-like, kinase, Ste20, Hippo/Yap, signaling, Other, Kinases, 6482, Tocris Bioscience

5 篇 XMU MP 1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 XMU MP 1 的部分引用包括:

Hong Wei et al (2021) Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional. Nat Commun 12 4566 PMID: 34315881

Turunen et al (2019) FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis. Cell Death Differ PMID: 30903103

Bing et al (2022) The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1. Nat Cell Biol 24 74-87 PMID: 35027733

Ying et al (2020) Mammalian STE20-Like Kinase 2 Promotes Lipopolysaccharides-Mediated Cardiomyocyte Inflammation and Apoptosis by Enhancing Mitochondrial Fission. Front Physiol 11 897 PMID: 32848850

Janneke N et al (2020) Yap1-Driven Intestinal Repair Is Controlled by Group 3 Innate Lymphoid Cells. Cell Rep 30 37-45.e3 PMID: 31914395


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