XMU MP 1

Cat. No. 6482 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent and selective MST1/2 inhibitor; orally bioavailable

化学名： 4-[(6,10-Dihydro-5,10-dimethyl-6-oxo-5H-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide

纯度： ≥98% (HPLC)

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for XMU MP 1

XMU MP 1 is a potent and selective ATP-competitive mammalian sterile 20-like kinase (MST) 1/2 inhibitor (IC₅₀ values are 38.1 and 71.1 nM for MST2 and MST1, respectively). Enhances activity of downstream YAP in vitro. Augments mouse intestinal repair and promotes liver repair and regeneration in a mouse model of acute and chronic liver injury. Orally bioavailable.

许可信息

Sold under license from Dana-Farber Cancer Institute.

化合物库 for XMU MP 1

XMU MP 1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for XMU MP 1

分子量	416.48
公式	C₁₇H₁₆N₆O₃S₂
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	2061980-01-4
PubChem ID	121499143
InChI Key	YRDHKIFCGOZTGD-UHFFFAOYSA-N
Smiles	CN1C2=C(C(N(C3=CN=C(N=C13)NC4=CC=C(S(N)(=O)=O)C=C4)C)=O)SC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for XMU MP 1

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	41.65	100

制备储备液 for XMU MP 1

以下数据基于产品分子量 416.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.4 mL	12.01 mL	24.01 mL
5 mM	0.48 mL	2.4 mL	4.8 mL
10 mM	0.24 mL	1.2 mL	2.4 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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产品说明书 for XMU MP 1

分析证书/产品说明书

化学品安全技术说明书

参考文献 for XMU MP 1

参考文献是支持产品生物活性的出版物。

Fan et al (2016) Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration. Sci.Transl.Med. 8 352 PMID: 27535619

Ray et al (2016) Therapy: Targeting liver tissue repair and regeneration. Nat.Rev.Gastroenterol.Hepatol. 13 559 PMID: 27605063

Crunkhorn et al (2016) Regenerative medicine: Inhibiting Hippo repairs tissue. Nat.Rev.Drug Discov. 15 678 PMID: 27681796

If you know of a relevant reference for XMU MP 1, please let us know.

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