Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewXMU MP 1 is a potent and selective ATP-competitive mammalian sterile 20-like kinase (MST) 1/2 inhibitor (IC50 values are 38.1 and 71.1 nM for MST2 and MST1, respectively). Enhances activity of downstream YAP in vitro. Augments mouse intestinal repair and promotes liver repair and regeneration in a mouse model of acute and chronic liver injury. Orally bioavailable.
Sold under license from Dana-Farber Cancer Institute.
XMU MP 1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。
分子量 | 416.48 |
公式 | C17H16N6O3S2 |
储存 | Store at -20°C |
纯度 | ≥98% (HPLC) |
CAS Number | 2061980-01-4 |
PubChem ID | 121499143 |
InChI Key | YRDHKIFCGOZTGD-UHFFFAOYSA-N |
Smiles | CN1C2=C(C(N(C3=CN=C(N=C13)NC4=CC=C(S(N)(=O)=O)C=C4)C)=O)SC=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
DMSO | 41.65 | 100 |
以下数据基于产品分子量 416.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.4 mL | 12.01 mL | 24.01 mL |
5 mM | 0.48 mL | 2.4 mL | 4.8 mL |
10 mM | 0.24 mL | 1.2 mL | 2.4 mL |
50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
参考文献是支持产品生物活性的出版物。
Fan et al (2016) Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration. Sci.Transl.Med. 8 352 PMID: 27535619
Ray et al (2016) Therapy: Targeting liver tissue repair and regeneration. Nat.Rev.Gastroenterol.Hepatol. 13 559 PMID: 27605063
Crunkhorn et al (2016) Regenerative medicine: Inhibiting Hippo repairs tissue. Nat.Rev.Drug Discov. 15 678 PMID: 27681796
If you know of a relevant reference for XMU MP 1, please let us know.
关键词: XMU MP 1, XMU MP 1 supplier, XMUMP1, potent, selective, MST1, MST2, Inhibitors, inhibits, tissue, regeneration, liver, repair, orally, bioavailable, mammalian, sterile, 20-like, kinase, Ste20, Hippo/Yap, signaling, Other, Kinases, 6482, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 XMU MP 1 的部分引用包括:
Hong Wei et al (2021) Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional. Nat Commun 12 4566 PMID: 34315881
Turunen et al (2019) FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis. Cell Death Differ PMID: 30903103
Bing et al (2022) The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1. Nat Cell Biol 24 74-87 PMID: 35027733
Ying et al (2020) Mammalian STE20-Like Kinase 2 Promotes Lipopolysaccharides-Mediated Cardiomyocyte Inflammation and Apoptosis by Enhancing Mitochondrial Fission. Front Physiol 11 897 PMID: 32848850
Janneke N et al (2020) Yap1-Driven Intestinal Repair Is Controlled by Group 3 Innate Lymphoid Cells. Cell Rep 30 37-45.e3 PMID: 31914395
您是否知道使用了 Tocris XMU MP 1 的优秀论文? 请告知我们.
目前没有该产品的评论。 Be the first to review XMU MP 1 and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image