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Submit ReviewZM 39923 hydrochloride is a potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3). pIC50 values are 7.1, 5.6, 4.4, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Breaks down in neutral buffer (t½ = 36 mins, pH 7.43, 25°C) to form ZM 449829 (Cat. No. 1366).
Sold with the permission of AstraZeneca Ltd.
ZM 39923 hydrochloride is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。
分子量 | 367.92 |
公式 | C23H25NO.HCl |
储存 | Desiccate at +4°C |
纯度 | ≥99% (HPLC) |
CAS Number | 1021868-92-7 |
PubChem ID | 176406 |
InChI Key | NJTUORMLOPXPBY-UHFFFAOYSA-N |
Smiles | Cl.CC(C)N(CCC(=O)C1=CC=C2C=CC=CC2=C1)CC1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Brown et al (2000) Naphthyl ketones: a new class of janus kinase 3 inhibitors. Bioorg.Med.Chem.Lett. 10 575 PMID: 10741557
关键词: ZM 39923 hydrochloride, ZM 39923 hydrochloride supplier, Potent, selective, JAK3, inhibitors, inhibits, Janus, Activated, Kinase, JAK, Kinases, ZM39923, hydrochloride, HCl, AstraZeneca, 58753-54-1, 1367, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 ZM 39923 hydrochloride 的部分引用包括:
Rogers and Gahring (2015) Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways. Autophagy 10 e0143319 PMID: 26619345
Vidro-Kotchan et al (2011) NBHA reduces acrolein-induced changes in ARPE-19 cells: possible involvement of TGFβ. Curr Eye Res 36 370 PMID: 21309688
Schaertl et al (2010) A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors. J Biomol Screen 15 478 PMID: 20395409
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