ZM 39923 hydrochloride

Cat. No. 1367 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent, selective JAK3 inhibitor

化学名： 3-benzylisopropylamino-1-naphthalen-2-yl-propan-1-one hydrochloride

纯度： ≥99% (HPLC)

引用文献 (3)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for ZM 39923 hydrochloride

ZM 39923 hydrochloride is a potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3). pIC₅₀ values are 7.1, 5.6, 4.4, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Breaks down in neutral buffer (t_½ = 36 mins, pH 7.43, 25°C) to form ZM 449829 (Cat. No. 1366).

许可信息

Sold with the permission of AstraZeneca Ltd.

化合物库 for ZM 39923 hydrochloride

ZM 39923 hydrochloride is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for ZM 39923 hydrochloride

分子量	367.92
公式	C₂₃H₂₅NO.HCl
储存	Desiccate at +4°C
纯度	≥99% (HPLC)
CAS Number	1021868-92-7
PubChem ID	176406
InChI Key	NJTUORMLOPXPBY-UHFFFAOYSA-N
Smiles	Cl.CC(C)N(CCC(=O)C1=CC=C2C=CC=CC2=C1)CC1=CC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ZM 39923 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	36.79	100

制备储备液 for ZM 39923 hydrochloride

以下数据基于产品分子量 367.92。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.72 mL	13.59 mL	27.18 mL
5 mM	0.54 mL	2.72 mL	5.44 mL
10 mM	0.27 mL	1.36 mL	2.72 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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产品说明书 for ZM 39923 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for ZM 39923 hydrochloride

参考文献是支持产品生物活性的出版物。

Brown et al (2000) Naphthyl ketones: a new class of janus kinase 3 inhibitors. Bioorg.Med.Chem.Lett. 10 575 PMID: 10741557

If you know of a relevant reference for ZM 39923 hydrochloride, please let us know.

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3 篇 ZM 39923 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ZM 39923 hydrochloride 的部分引用包括：

Rogers and Gahring (2015) Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways. Autophagy 10 e0143319 PMID: 26619345

Vidro-Kotchan et al (2011) NBHA reduces acrolein-induced changes in ARPE-19 cells: possible involvement of TGFβ. Curr Eye Res 36 370 PMID: 21309688

Schaertl et al (2010) A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors. J Biomol Screen 15 478 PMID: 20395409

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