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Submit ReviewAT 7867
Description: Potent pan-Akt and PKA inhibitor
Chemical Name: 4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for AT 7867
AT 7867 is a potent pan-Akt (protein kinase B) and protein kinase A (PKA) inhibitor (IC50 values are 32, 17, 47 and 20 nM for Akt1, Akt2, Akt3 and PKA, respectively). Also inhibits p70-S6 kinase (p70S6K, IC50 = 85 nM). Inhibits Akt signaling and proliferation of multiple human cancer cell lines, including breast, prostate and colon. Promotes proliferation of iPSC-derived PDX1+ pancreatic progenitor cells (PPCs).
Compound Libraries for AT 7867
AT 7867 is also offered as part of the Tocriscreen Antiviral Library, Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
Technical Data for AT 7867
| M. Wt | 374.31 |
| Formula | C20H20ClN3.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2624336-89-4 |
| InChI Key | YZMRULKVIVBSAA-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(C2(C3=CC=C(C4=CNN=C4)C=C3)CCNCC2)C=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AT 7867
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.43 | 100 | |
| ethanol | 3.74 | 10 |
Preparing Stock Solutions for AT 7867
The following data is based on the product molecular weight 374.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.67 mL | 13.36 mL | 26.72 mL |
| 5 mM | 0.53 mL | 2.67 mL | 5.34 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.67 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
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Product Datasheets for AT 7867
References for AT 7867
References are publications that support the biological activity of the product.
Grimshaw et al (2010) AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth. Mol.Cancer Ther. 9 1100 PMID: 20423992
Kimura et al (2017) Small molecule AT7867 proliferates PDX1-expressing pancreatic progenitor cells derived from human pluripotent stem cells. Stem Cell Res. 24 61 PMID: 28843156
If you know of a relevant reference for AT 7867, please let us know.
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Citations for AT 7867
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