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Submit Reviewcis VH 298
Description: Negative control for VH 298
Chemical Name: (2S,4S)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for cis VH 298
cis VH 298 is a negative control for VH 298 (Cat.No. 6156). Exhibits no detectable binding of VHL.
Licensing Information
Sold under licence from the University of Dundee
External Portal Information for cis VH 298
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of VH 298 is reviewed on the chemical probes website.
Compound Libraries for cis VH 298
cis VH 298 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.
Technical Data for cis VH 298
| M. Wt | 523.65 |
| Formula | C27H33N5O4S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2097381-86-5 |
| PubChem ID | 127021044 |
| InChI Key | NDVQUNZCNAMROD-JAXLGGSGSA-N |
| Smiles | O=C(N[C@@H](C(C)(C)C)C(N1C[C@H](C[C@H]1C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)O)=O)C4(C#N)CC4 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for cis VH 298
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.37 | 100 | |
| ethanol | 52.37 | 100 |
Preparing Stock Solutions for cis VH 298
The following data is based on the product molecular weight 523.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.91 mL | 9.55 mL | 19.1 mL |
| 5 mM | 0.38 mL | 1.91 mL | 3.82 mL |
| 10 mM | 0.19 mL | 0.95 mL | 1.91 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
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Product Datasheets for cis VH 298
References for cis VH 298
References are publications that support the biological activity of the product.
Frost et al (2016) Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition. Nat.Commun. 7 13312 PMID: 27811928
If you know of a relevant reference for cis VH 298, please let us know.
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Citations for cis VH 298
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