TC JL 37

Cat. No. 6125 Submit a Review Datasheet / COA / SDS

Pricing	Availability		Qty

Description: Potent TYK2 inhibitor

Chemical Name: 2-Chloro-4-cyano-6-fluoro-N-[2-[[[(1R,2R)-2-fluorocyclopropyl]carbonyl]amino]-4-pyridinyl]benzamide

Purity: ≥98% (HPLC)

Datasheet

Citations

Reviews

Pathways (1)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for TC JL 37

TC JL 37 is a potent inhibitor of tyrosine kinase 2 (TYK2, K_i = 1.6 nM). Shows some selectivity for TYK2 over JAK1/2/3. Inhibits IFNγ production in vivo in mice. Orally bioavailable.

Compound Libraries for TC JL 37

TC JL 37 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for TC JL 37

M. Wt	376.74
Formula	C₁₇H₁₁ClF₂N₄O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1258294-34-6
PubChem ID	56934550
InChI Key	NKALKXMQBFLGQI-CMPLNLGQSA-N
Smiles	F[C@@H]1C[C@@H]1C(NC2=CC(NC(C3=C(C=C(C#N)C=C3F)Cl)=O)=CC=N2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for TC JL 37

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	37.67	100

Preparing Stock Solutions for TC JL 37

The following data is based on the product molecular weight 376.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.65 mL	13.27 mL	26.54 mL
5 mM	0.53 mL	2.65 mL	5.31 mL
10 mM	0.27 mL	1.33 mL	2.65 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

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Product Datasheets for TC JL 37

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for TC JL 37

References are publications that support the biological activity of the product.

Liang et al (2013) Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors. J.Med.Chem. 56 4521 PMID: 23668484

If you know of a relevant reference for TC JL 37, please let us know.

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Keywords: TC JL 37, TC JL 37 supplier, TCJL37, Tyrosine, kinase, 2, inhibitors, inhibits, TYK2, potent, orally, bioavailable, JAK, Kinase, 6125, Tocris Bioscience

Citations for TC JL 37

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Pathways for TC JL 37

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.