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AT 7867

Cat. No. 7001 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent pan-Akt and PKA inhibitor
化学名： 4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine hydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献
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通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AT 7867

AT 7867 is a potent pan-Akt (protein kinase B) and protein kinase A (PKA) inhibitor (IC50 values are 32, 17, 47 and 20 nM for Akt1, Akt2, Akt3 and PKA, respectively). Also inhibits p70-S6 kinase (p70S6K, IC50 = 85 nM). Inhibits Akt signaling and proliferation of multiple human cancer cell lines, including breast, prostate and colon. Promotes proliferation of iPSC-derived PDX1+ pancreatic progenitor cells (PPCs).

化合物库 for AT 7867

AT 7867 is also offered as part of the Tocriscreen Antiviral Library, Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for AT 7867

分子量 374.31
公式 C20H20ClN3.HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2624336-89-4
InChI Key YZMRULKVIVBSAA-UHFFFAOYSA-N
Smiles ClC1=CC=C(C2(C3=CC=C(C4=CNN=C4)C=C3)CCNCC2)C=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AT 7867

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 37.43 100
ethanol 3.74 10

制备储备液 for AT 7867

以下数据基于产品分子量 374.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.67 mL 13.36 mL 26.72 mL
5 mM 0.53 mL 2.67 mL 5.34 mL
10 mM 0.27 mL 1.34 mL 2.67 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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参考文献 for AT 7867

参考文献是支持产品生物活性的出版物。

Grimshaw et al (2010) AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth. Mol.Cancer Ther. 9 1100 PMID: 20423992

Kimura et al (2017) Small molecule AT7867 proliferates PDX1-expressing pancreatic progenitor cells derived from human pluripotent stem cells. Stem Cell Res. 24 61 PMID: 28843156

If you know of a relevant reference for AT 7867, please let us know.

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Pathways for AT 7867

Akt Signaling Pathway

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.