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AZD 1480

Cat. No. 5617 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective JAK2 inhibitor; antiangiogenic
化学名： 5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidine-2,4-diamine
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for AZD 1480

AZD 1480 is a potent and selective JAK2 inhibitor (IC50 < 3 nM). Exhibits >50-fold selectivity for JAK2 over JAK3. Exhibits antitumor effects and inhibits formation of lung metastases in a mouse renal cancer model. Also inhibits STAT3 signaling, tumor angiogenesis and myeloid cell migration in vivo.

化合物库 for AZD 1480

AZD 1480 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for AZD 1480

分子量 348.77
公式 C14H14ClFN8
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 935666-88-9
PubChem ID 16659841
InChI Key PDOQBOJDRPLBQU-QMMMGPOBSA-N
Smiles C[C@@H](C1=NC=C(F)C=N1)NC2=NC=C(Cl)C(NC3=NNC(C)=C3)=N2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for AZD 1480

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 34.88 100
ethanol 34.88 100

制备储备液 for AZD 1480

以下数据基于产品分子量 348.77。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.87 mL 14.34 mL 28.67 mL
5 mM 0.57 mL 2.87 mL 5.73 mL
10 mM 0.29 mL 1.43 mL 2.87 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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参考文献 for AZD 1480

参考文献是支持产品生物活性的出版物。

Ioannidis S et al (2011) Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway. J.Med.Chem. 54 262 PMID: 21138246

Xin et al (2011) Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480. Cancer Res. 71 6601 PMID: 21920898

If you know of a relevant reference for AZD 1480, please let us know.

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关键词: AZD 1480, AZD 1480 supplier, AZD1480, JAK2, inhibitors, cancer, anticancers, metastasis, angiogenesis, STAT3, signaling, potent, selective, inhibits, JAK, Antiangiogenics, Kinase, 5617, Tocris Bioscience

2 篇 AZD 1480 的引用文献

引用文献是使用了 Tocris 产品的出版物。 AZD 1480 的部分引用包括：

John D et al (2021) Nitric Oxide Induces a Janus Kinase-1-Dependent Inflammatory Response in Primary Murine Astrocytes. ASN Neuro 13 17590914211033650 PMID: 34498493

Maarten H et al (2020) Cucurbitacin E and I target the JAK/STAT pathway and induce apoptosis in Sézary cells. Biochem Biophys Rep 24 100832 PMID: 33102814

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Pathways for AZD 1480

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.