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说明： Negative control for VH 298
化学名： (2S,4S)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
纯度： ≥98% (HPLC)
生物活性 for cis VH 298
cis VH 298 is a negative control for VH 298 (Cat.No. 6156). Exhibits no detectable binding of VHL.
许可信息
Sold under licence from the University of Dundee
External Portal Information for cis VH 298
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of VH 298 is reviewed on the chemical probes website.
化合物库 for cis VH 298
cis VH 298 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。
技术数据 for cis VH 298
| 分子量 | 523.65 |
| 公式 | C27H33N5O4S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2097381-86-5 |
| PubChem ID | 127021044 |
| InChI Key | NDVQUNZCNAMROD-JAXLGGSGSA-N |
| Smiles | O=C(N[C@@H](C(C)(C)C)C(N1C[C@H](C[C@H]1C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)O)=O)C4(C#N)CC4 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for cis VH 298
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 52.37 | 100 | |
| ethanol | 52.37 | 100 |
制备储备液 for cis VH 298
以下数据基于产品分子量 523.65。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.91 mL | 9.55 mL | 19.1 mL |
| 5 mM | 0.38 mL | 1.91 mL | 3.82 mL |
| 10 mM | 0.19 mL | 0.95 mL | 1.91 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
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产品说明书 for cis VH 298
参考文献 for cis VH 298
参考文献是支持产品生物活性的出版物。
Frost et al (2016) Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition. Nat.Commun. 7 13312 PMID: 27811928
If you know of a relevant reference for cis VH 298, please let us know.
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关键词: cis VH 298, cis VH 298 supplier, Inhibitors, Inhibition, VHL, HIF-alpha, HIF-a, HIF-α, VH298, cisVH298, von, Hippel-Lindau, protein, E3, uniquitin, ligase, Hypoxia, Inducible, Factors, Ubiquitin, Ligases, 6157, Tocris Bioscience
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