CP 690550 citrate

Name: CP 690550 citrate
Brand: Tocris Bioscience
SKU: 4556
Rating: 5 (1 reviews)

Cat. No. 4556 6 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent JAK inhibitor

别名： Tofacitinib citrate

化学名： (3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-1-piperidinepropanenitrile citrate

纯度： ≥99% (HPLC)

说明书

引用文献 (6)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for CP 690550 citrate

CP 690550 citrate is a potent JAK inhibitor (IC₅₀ values are 1, 20, and 112 nM for JAK3, JAK2 and JAK1 respectively). Orally active immunosuppressant; exhibits efficacy in rodent rheumatoid arthritis models.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

External Portal Information for CP 690550 citrate

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CP 690550 (Tofacitinib) is reviewed on the chemical probes website.

化合物库 for CP 690550 citrate

CP 690550 citrate is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library, Tocriscreen Epigenetics Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for CP 690550 citrate

分子量	504.49
公式	C₁₆H₂₀N₆O.C₆H₈O₇
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	540737-29-9
PubChem ID	10174505
InChI Key	SYIKUFDOYJFGBQ-YLAFAASESA-N
Smiles	C[C@H]1[C@@H](N(C2=NC=NC3=C2C=CN3)C)CN(C(CC#N)=O)CC1.OC(CC(O)=O)(C(O)=O)CC(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for CP 690550 citrate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	50.45	100

制备储备液 for CP 690550 citrate

以下数据基于产品分子量 504.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.98 mL	9.91 mL	19.82 mL
5 mM	0.4 mL	1.98 mL	3.96 mL
10 mM	0.2 mL	0.99 mL	1.98 mL
50 mM	0.04 mL	0.2 mL	0.4 mL

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产品说明书 for CP 690550 citrate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for CP 690550 citrate

参考文献是支持产品生物活性的出版物。

Jiang et al (2008) Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550). J.Med.Chem. 51 8012 PMID: 19053756

Flanagan et al (2010) Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection. J.Med.Chem. 53 8468 PMID: 21105711

Dowty et al (2013) Preclinical to clinical translation of tofacitinib, a Janus kinase inhibitor, in rheumatoid arthritis. J.Pharmacol.Exp.Ther. 348 165 PMID: 24218541

If you know of a relevant reference for CP 690550 citrate, please let us know.

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6 篇 CP 690550 citrate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 CP 690550 citrate 的部分引用包括：

Chin Wai et al (2022) Interleukins 4 and 21 Protect Anti-IgM Induced Cell Death in Ramos B Cells: Implication for Autoimmune Diseases. Front Immunol 13 919854 PMID: 35911775

Tetsuro et al (2020) Targeted therapy guided by single-cell transcriptomic analysis in drug-induced hypersensitivity syndrome: a case report. Nat Med 26 236-243 PMID: 31959990

Yu et al (2017) PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development. Nat Commun 8 1457 PMID: 29133930

Zhu et al (2015) Adenosine 5'-monophosphate-activated protein kinase regulates IL-10-mediated anti-inflammatory signaling pathways in macrophages. Nat Commun 194 584 PMID: 25512602

Tactacan et al (2015) The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling. Mol Cancer 14 139 PMID: 26215634

Eun-Kyoung et al (2017) The Peptidylarginine Deiminase Inhibitor Cl-Amidine Suppresses Inducible Nitric Oxide Synthase Expression in Dendritic Cells. Int J Mol Sci 18 PMID: 29077055

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