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Nutlin 3a

Cat. No. 6075 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)
化学名： 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone
纯度： ≥97% (HPLC)
说明书
引用文献 (2)
评论
文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Nutlin 3a

Nutlin 3a is an MDM2 antagonist (IC50 = 90 nM); inhibits the MDM2-p53 interaction. Active enantiomer of Nutlin-3 (Cat. No. 3984). Induces expression for P53 regulated genes. Suppresses tumor growth in vivo >98% in prostate cancer and osteosarcoma cancer models. Antiproliferative.

化合物库 for Nutlin 3a

Nutlin 3a is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Nutlin 3a

分子量 581.49
公式 C30H30Cl2N4O4
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 675576-98-4
PubChem ID 11433190
InChI Key BDUHCSBCVGXTJM-WUFINQPMSA-N
Smiles ClC1=CC=C([C@H]2[C@H](N(C(N3CC(NCC3)=O)=O)C(C4=CC=C(OC)C=C4OC(C)C)=N2)C5=CC=C(Cl)C=C5)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Nutlin 3a

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 58.15 100
ethanol 58.15 100

制备储备液 for Nutlin 3a

以下数据基于产品分子量 581.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.72 mL 8.6 mL 17.2 mL
5 mM 0.34 mL 1.72 mL 3.44 mL
10 mM 0.17 mL 0.86 mL 1.72 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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参考文献 for Nutlin 3a

参考文献是支持产品生物活性的出版物。

Tovar et al (2006) Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc.Natl.Acad.Sci.USA. 103 1888 PMID: 16443686

Vassilev et al (2004) In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303 844 PMID: 14704432

If you know of a relevant reference for Nutlin 3a, please let us know.

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关键词: Nutlin 3a, Nutlin 3a supplier, Nutlin3a, p53, activators, MDM2, antagonism, antagonists, p53-MDM2, activates, Ubiquitin, E3, Ligases, 6075, Tocris Bioscience

2 篇 Nutlin 3a 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Nutlin 3a 的部分引用包括：

Slobodan et al (2020) Embryonic Barcoding of Equipotent Mammary Progenitors Functionally Identifies Breast Cancer Drivers. Cell Stem Cell 26 403-419.e4 PMID: 32059806

Catherine et al (2021) p53 mitigates the effects of oncogenic HRAS in urothelial cells via the repression of MCOLN1. iScience 24 102701 PMID: 34222845

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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