PF 06551600 malonate

Name: PF 06551600 malonate
Brand: Tocris Bioscience
SKU: 6506
Rating: 5 (1 reviews)

Cat. No. 6506 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective JAK3 inhibitor

化学名： 1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one malate

纯度： ≥98% (HPLC)

说明书

引用文献

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for PF 06551600 malonate

PF 06551600 malonate is a potent and selective JAK3 inhibitor (IC₅₀ = 33.1 μM). Exhibits no significant activity against a panel of other kinases including JAK1, JAK2 and TYK2. Inhibits phosphorylation of STAT5, induced by IL-2, IL-4, IL-7 and IL-15. Suppresses Th1 and Th17 T-cell differentiation and function in vitro. Reduces paw swelling in a rat model of arthritis and reduces disease severity in a rat EAE model.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

化合物库 for PF 06551600 malonate

PF 06651600 malonate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for PF 06551600 malonate

分子量	389.41
公式	C₁₅H₁₉N₅O.C₃H₄O₄
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	2140301-97-7
PubChem ID	124203830
InChI Key	QMPMPSGDPRHZCG-VZXYPILPSA-N
Smiles	C[C@H]1CC[C@@H](NC2=C3C=CNC3=NC=N2)CN1C(C=C)=O.OC(CC(O)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PF 06551600 malonate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	38.94	100
	DMSO	38.94	100

制备储备液 for PF 06551600 malonate

以下数据基于产品分子量 389.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.57 mL	12.84 mL	25.68 mL
5 mM	0.51 mL	2.57 mL	5.14 mL
10 mM	0.26 mL	1.28 mL	2.57 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

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产品说明书 for PF 06551600 malonate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for PF 06551600 malonate

参考文献是支持产品生物活性的出版物。

Thorarensen et al (2017) Design of a Janus Kinase 3 (JAK3) specific inhibitor 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) allowing for the interrogation of JAK3 signaling in humans. J.Med.Chem. 60 1971 PMID: 28139931

Telliez et al (2016) Discovery of a JAK3-selective inhibitor: functional differentiation of JAK3-selective inhibition over pan-JAK or JAK1-selective inhibition. ACS Chem.Biol. 11 3442 PMID: 27791347

If you know of a relevant reference for PF 06551600 malonate, please let us know.

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