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SMIP 004

Cat. No. 7192 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： SKP2 (S-phase kinase-associated protein 2) inhibitor; upregulates p27 and arrests cell cycle in G1 phase
化学名： N-(4-Butyl-2-methylphenyl)acetamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SMIP 004

SMIP 004 is an SKP2 (S-phase kinase-associated protein 2) inhibitor. Upregulates p27 and activates the unfolded protein response (UPR) in LNCaP prostate cancer cells overexpressing SKP2. Also induces oxidative stress. Induces proteasomal degradation of cyclin D1 and acts as CDK2 inhibitor. Arrests cell cycle in G1 phase and induces apoptosis in prostate cancer cells, but not normal cells in vitro. Inhibits growth of breast and prostate cancer xenografts in mice. Also induces autophagy and reduces replication of MERS-CoV in VeroB4 cells.

化合物库 for SMIP 004

SMIP 004 is also offered as part of the Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for SMIP 004

分子量 205.3
公式 C13H19NO
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 143360-00-3
PubChem ID 2747581
InChI Key ZFVMECVBUGMWIX-UHFFFAOYSA-N
Smiles CCCCC1=CC(C)=C(NC(C)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SMIP 004

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 20.53 100

制备储备液 for SMIP 004

以下数据基于产品分子量 205.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.87 mL 24.35 mL 48.71 mL
5 mM 0.97 mL 4.87 mL 9.74 mL
10 mM 0.49 mL 2.44 mL 4.87 mL
50 mM 0.1 mL 0.49 mL 0.97 mL

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参考文献 for SMIP 004

参考文献是支持产品生物活性的出版物。

Rico-Bautista et al (2010) Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells. BMC Biol. 8 153 PMID: 21182779

Rico-Bautista et al (2013) Small molecule-induced mitochondrial disruption directs prostate cancer inhibition via UPR signaling. Oncotarget 4 1212 PMID: 23902736

Gassen et al (2019) SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection. Nat.Commun. 10 5770 PMID: 31852899

If you know of a relevant reference for SMIP 004, please let us know.

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关键词: SMIP 004, SMIP 004 supplier, SMIP004, S-phase, kinase-associated, protein, 2, SKP2, E3, ligase, inhibitors, inhibits, p27, upregulates, MERS-CoV, unfolded, response, UPR, activates, activators, CDK2, CKI, cyclin, dependent, kinase, ubiquitin, Ubiquitin, Ligases, Coronavirus, Other, ER, stress/UPR, CDK1, Subfamily, 7192, Tocris Bioscience

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