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TC JL 37

Cat. No. 6125 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent TYK2 inhibitor
化学名： 2-Chloro-4-cyano-6-fluoro-N-[2-[[[(1R,2R)-2-fluorocyclopropyl]carbonyl]amino]-4-pyridinyl]benzamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TC JL 37

TC JL 37 is a potent inhibitor of tyrosine kinase 2 (TYK2, Ki = 1.6 nM). Shows some selectivity for TYK2 over JAK1/2/3. Inhibits IFNγ production in vivo in mice. Orally bioavailable.

化合物库 for TC JL 37

TC JL 37 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for TC JL 37

分子量 376.74
公式 C17H11ClF2N4O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1258294-34-6
PubChem ID 56934550
InChI Key NKALKXMQBFLGQI-CMPLNLGQSA-N
Smiles F[C@@H]1C[C@@H]1C(NC2=CC(NC(C3=C(C=C(C#N)C=C3F)Cl)=O)=CC=N2)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TC JL 37

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 37.67 100

制备储备液 for TC JL 37

以下数据基于产品分子量 376.74。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.65 mL 13.27 mL 26.54 mL
5 mM 0.53 mL 2.65 mL 5.31 mL
10 mM 0.27 mL 1.33 mL 2.65 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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参考文献 for TC JL 37

参考文献是支持产品生物活性的出版物。

Liang et al (2013) Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors. J.Med.Chem. 56 4521 PMID: 23668484

If you know of a relevant reference for TC JL 37, please let us know.

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关键词: TC JL 37, TC JL 37 supplier, TCJL37, Tyrosine, kinase, 2, inhibitors, inhibits, TYK2, potent, orally, bioavailable, JAK, Kinase, 6125, Tocris Bioscience

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Pathways for TC JL 37

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.