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Submit ReviewPyridone 6
说明： Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable
别名： JAK inhibitor I
化学名： 2-(1,1-Dimethylethyl)-9-fluoro-1,6-dihydro-7H-benz[h]imidazo[4,5-f]isoquinolin-7-one
纯度： ≥98% (HPLC)
生物活性 for Pyridone 6
Pyridone 6 is a potent pan-JAK inhibitor; ATP-competitive inhibitor of JAK 1/2/3 and Tyk2 (IC50 values are 1, 5, 15 and 1 nM, respectively). Inhibits other kinases tested at 130 nM to >10 μM. Inhibits IL-2- and IL-4-dependent proliferation of CTLL cells and blocks STAT5 phosphorylation. Also inhibits Th1 and Th2 development, and promotes Th17 differentiation from naive T cells. When used in combination with Retinoic acid, LY 294002 and CCG 1423, it induces intermediate mesoderm differentiation from ESCs. Inhibits growth of primary myeloma cells grown in the presence of bone marrow stromal cells. Cell-permeable.
化合物库 for Pyridone 6
Pyridone 6 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library, Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for Pyridone 6
| 分子量 | 309.34 |
| 公式 | C18H16FN3O |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 457081-03-7 |
| PubChem ID | 5494425 |
| InChI Key | VNDWQCSOSCCWIP-UHFFFAOYSA-N |
| Smiles | CC(C)(C1=NC2=C3C=CNC(C3=C4C=C(C=CC4=C2N1)F)=O)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Pyridone 6
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 30.93 | 100 | |
| ethanol | 15.47 | 50 |
制备储备液 for Pyridone 6
以下数据基于产品分子量 309.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.23 mL | 16.16 mL | 32.33 mL |
| 5 mM | 0.65 mL | 3.23 mL | 6.47 mL |
| 10 mM | 0.32 mL | 1.62 mL | 3.23 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.65 mL |
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产品说明书 for Pyridone 6
参考文献 for Pyridone 6
参考文献是支持产品生物活性的出版物。
Mae et al (2010) Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells. Biochem.Biophys.Res.Commun. 393 877 PMID: 20171952
Thompson et al (2002) Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor. Bioorg.Med.Chem.Lett. 12 1219 PMID: 11934592
If you know of a relevant reference for Pyridone 6, please let us know.
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关键词: Pyridone 6, Pyridone 6 supplier, CMP, 6, Pyridon, pan, JAK, inhibitor, I, potent, ATP, competitive, 1, JAK2, JAK3, Tyk2, STAT5, mesoderm, differentiation, myeloma, Kinase, ESCs, and, iPSC, Cardiomyocyte, Stem, Cells, 6577, Tocris Bioscience
1 篇 Pyridone 6 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Pyridone 6 的部分引用包括：
Brian P et al (2021) Fibrillar α-synuclein induces neurotoxic astrocyte activation via RIP kinase signaling and NF-κB. Cell Death Dis 12 756 PMID: 34333522
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