Stem Cell Reprogramming Other
| Cat. No. | Product Name / Activity |
|---|---|
| 4055 | L-Ascorbic acid |
| Enhances the generation of iPSCs; increases reprogramming efficiency | |
| 3842 | 5-Azacytidine |
| DNA methyltransferase inhibitor; improves reprogramming efficiency | |
| 1544 | (±)-Bay K 8644 |
| Ca2+ channel activator (L-type); aids generation of iPSCs from MEFs | |
| 5819 | Bexarotene |
| Potent and selective RXR agonist; induces brown adipogenic reprogramming from myoblasts | |
| 5989 | BIRB 796 |
| Used in the reprogramming of somatic cells to ciPSCs; high affinity and selective p38 kinase inhibitor | |
| 3364 | BIX 01294 |
| GLP and G9a inhibitor; potentiates induction of iPSCs | |
| 5015 | 5-BrdU |
| Enhances Yamanaka factor reprogramming and replaces Oct-4 in transcription factor-mediated reprogramming; synthetic thymidine analog | |
| 3302 | CD 3254 |
| Promotes mouse fibroblasts chemical reprogramming; Potent and selective RXRa agonist | |
| 6695 | CHIR 98014 |
| Highly potent and selective GSK-3 inhibitor; can be used in differentiation and reprogramming of stem cells | |
| 4423 | CHIR 99021 |
| Highly selective GSK-3 inhibitor; enables reprogramming of mouse embryonic fibroblasts into iPS cells | |
| 7163 | Chroman 1 |
| Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogenesis | |
| 5331 | CPI 203 |
| Enhances reprogramming at low concentration; BET bromodomain inhibitor | |
| 4489 | DBZ |
| Notch signaling pathway inhibitor; stimulates formation of iPSCs | |
| 4703 | 3-Deazaneplanocin A hydrochloride |
| Histone methyltransferase inhibitor; enhances Oct4 expression in chemically-induced pluripotent stem cells | |
| 1425 | (S)-(+)-Dimethindene maleate |
| Allows formation of extended pluripotent stem (EPS) cells; also M2-selective antagonist | |
| 4126 | DMH-1 |
| Used in the reprogramming of somatic cells to ciPSCs; selective ALK2 inhibitor | |
| 3093 | Dorsomorphin dihydrochloride |
| Used in the reprogramming of somatic cells to ciPSCs; BMP type I receptor inhibitor | |
| 6340 | Epiblastin A |
| Converts epiblast stem cells to ESCs and promotes ESC self-renewal; CK1 inhibitor | |
| 5567 | EPZ 004777 |
| Improves reprogramming efficiency; highly potent DOT1L inhibitor | |
| 7807 | Hh-Ag1.5 |
| Promotes mouse embryonic fibroblasts reprogramming into neural stem cells; potent and high affinity Smo receptor agonist | |
| 3533 | IWP 2 |
| Used in the reprogramming of somatic cells to ciPSCs; PORCN inhibitor | |
| 6976 | JNJ 10198409 |
| Induces reprogramming of fibroblasts into functional cardiomyocytes (9C cocktail); potent PDGFRα and PDGFRβ inhbitor | |
| 1398 | Kenpaullone |
| Promotes generation of iPSCs from somatic cells; inhibits GSK-3β and cdks | |
| 7743 | Linifanib |
| Promotes generation and reprogramming of iPSCs; also potent inhibitor of PDGFRβ, KDR, FLT3 and CSF-1R | |
| 3268 | Minocycline hydrochloride |
| Allows formation of extended pluripotent stem (EPS) cells; also antibiotic | |
| 3656 | Neurodazine |
| Induces neurogenesis in mature skeletal muscle cells | |
| 5664 | O4I2 |
| Oct3/4 inducer; induces expression of pluripotent-associated genes | |
| 4192 | PD 0325901 |
| Selective inhibitor of MEK1/2; enhances generation of iPSCs | |
| 2653 | Pifithrin-μ |
| Inhibitor of p53-mitochondrial binding | |
| 6070 | Pladienolide B |
| Reprogram pluripotent hESCs into zigotic genome activation (ZGA)-like cells (ZLCs) | |
| 7739 | Polyamine Supplement x1000 (lyophilized) |
| Media supplement to boost cell growth; used as component of CEPT cocktail to enhance stem cell viability | |
| 3742 | RepSox |
| Selective TGF-βRI inhibitor; enhances reprogramming efficiency | |
| 3295 | RG 108 |
| Non-nucleoside DNA methyltransferase inhibitor; enhances efficiency of iPSC generation | |
| 7064 | Ruxolitinib |
| Used in the reprogramming of somatic cells to ciPSCs; JAK 1/2 inhibitor | |
| 6390 | SAG dihydrochloride |
| Used in the reprogramming of somatic cells to ciPSCs; Smo receptor agonist | |
| 4652 | SAHA |
| Increases efficiency of OSKM-induced reprogramming of MEFs to iPSCs; class I and II HDAC inhibitor | |
| 1614 | SB 431542 |
| Replaces SOX2 in reprogramming protocols; potent and selective inhibitor of TGF-βRI, ALK4 and ALK7 | |
| 2650 | SB 590885 |
| Used in the reprogramming of somatic cells to ciPSCs; B-Raf inhibitor inhibitor | |
| 4889 | SGC-CBP30 |
| Used in the reprogramming of somatic cells to ciPSCs; potent CBP/p300 BRD inhibitor | |
| 4297 | SMER 28 |
| Promotes reprogramming of fibroblasts to neural stem-like cells | |
| 3845 | Thiazovivin |
| Improves the efficiency of fibroblast reprogramming and induction of iPSCs; ROCK inhibitor | |
| 7340 | Tocriscreen Stem Cell Library |
| A library of 120 stem cell compounds (100 μL 10 mM DMSO solutions) to explore stem cell reprogramming, differentiation, proliferation and signaling | |
| 3852 | Tranylcypromine hydrochloride |
| Irreversible inhibitor of LSD1; enables reprogramming of mouse embryonic fibroblasts into iPS cells | |
| 1406 | Trichostatin A |
| Potent histone deacetylase inhibitor; induces accelerated dedifferentiation of primordial germ cells | |
| 0761 | TTNPB |
| Retinoic acid analog; enhances efficiency of reprogramming in CiPSCs | |
| 3861 | UNC 0224 |
| Used in the reprogramming of somatic cells to ciPSCs; G9a and GLP inhibitor | |
| 2815 | Valproic acid, sodium salt |
| Histone deacetylase inhibitor; enables induction of pluripotent stem cells from somatic cells | |
| 1254 | Y-27632 dihydrochloride |
| Selective ROCK inhibitor; part of cocktail used to induce neurons from fibroblasts | |
| 7000 | Y-27632 in solution New |
| Sterile-filtered 10 mM solution of Y-27632 pre-dissolved in water |
Stem Cell Research Product Guide
Our guide highlights the use of small molecules in stem cell research and cell therapy and lists relevant products.
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Our Stem Cells review gives an overview of the use of small molecules in the control of stem cell growth & differentiation and somatic cell reprogramming.
Request copyRequest PDFStem Cell Workflow Life Science Poster
Developed in-house, this poster summarizes how small molecules have been used in protocols across the stem cell workflow.
Request copyDownload PDFStem Cells Life Science Poster
Written by Rebecca Quelch and Stefan Przyborski, this poster summarizes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and potential uses.
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