New ProductsView all New Products by pharmacological action
Search for new products by date added, alphabetically, or by pharmacological action.
New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the New symbol.
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Bromodomain (BRD) Degraders | ||
| Cat. No. | Product Name / Activity | Date Added |
|---|---|---|
| 8152 | JQ dS-4 | Oct 2024 |
| BRG1/SMARCA4 Degrader (PROTAC®) | ||
Cyclin Dependent Kinase (CDK) Degraders | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7940 | HEMTAC 26 | Jan 2025 |
| CDK6 and CDK4 HSP90-mediated targeting chimera (HEMTAC) Degrader | ||
Inward Rectifier Potassium (Kir) Channels | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8151 | VU 0542270 | Sep 2024 |
| Selective inhibitor of Kir6.1 KATP channels | ||
Voltage-gated Potassium (KV) Channels | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8137 | Ebio1 | Feb 2025 |
| KCNQ2 activator | ||
Near Infrared (NIR) Fluorescent Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8881 | IRDye® 800CW, NHS ester | Feb 2025 |
| Near-infared dye (reactive group NHS ester) | ||
| 8879 | IRDye® 800CW, DBCO | Feb 2025 |
| Near-infared dye (reactive group DBCO) | ||
| 8880 | IRDye® 800CW, Maleimide | Feb 2025 |
| Near-infrared dye (Reactive group: maleimide) | ||
| 8877 | IRDye® 680RD, Maleimide | Feb 2025 |
| Near-infared dye (reactive group maleimide) | ||
| 8878 | IRDye® 680RD, NHS ester | Feb 2025 |
| Near-infared dye (reactive group NHS ester) | ||
Glucagon-Like Peptide 1 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7959 | LSN 3318839 | Sep 2024 |
| Glucagon-like peptide-1 receptor (GLP1-R) positive allosteric modulator | ||
CB2 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8835 | RNB 61 | Feb 2025 |
| Highly potent and selective CB2R agonist | ||
EZH2 | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8093 | Tazemetostat | Sep 2024 |
| Potent and selective EZH2 inhibitor | ||
Glycogen Synthase Kinase 3 | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8170 | CHIR 99021 in solution | Oct 2024 |
| Sterile-filtered 10 mM solution of CHIR 99021 pre-dissolved in DMSO | ||
Functionalized E3 Ligase Ligands | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8075 | VHF 543, amine | Feb 2025 |
| DCAF1 WD40 ligand with terminal amine for onward chemistry | ||
Ubiquitin E3 Ligases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8091 | KH-4-43 | Feb 2025 |
| Selective CUL4 inhibitor | ||
| 8047 | JP-2-196 alkyne | Feb 2025 |
| RNF126 chemical handle; alkyne functionalized version of JP-2-196 (Cat. No. 8046). | ||
| 8046 | JP-2-196 | Feb 2025 |
| RNF126 chemical handle | ||
| 7960 | PFI 7 | Jan 2025 |
| Selective GID4 antagonist | ||
Orphan 7-TM Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8131 | OX 04528 | Feb 2025 |
| Highly potent and selective GPR84 agonist | ||
ALK | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8832 | MU 1700 trihydrochloride | Feb 2025 |
| Potent and selective ALK1/2 inhibitor. Brain-penetrant | ||
Ancillary Material Grade Small Molecules | ||
| Cat. No. | Product Name / Activity | Date Added |
| TB0695-RMU | Retinoic acid | Nov 2024 |
| Retinoic acid synthesized to Ancillary Material Grade | ||
Inhibitor of Apoptosis | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8018 | 142D6 | Nov 2024 |
| Potent Lys-covalent pan-IAP inhibitor | ||
| 8065 | CST 530 | Jan 2025 |
| Monovalent IAP antagonist | ||
TR-FRET and FP Assay Reagents | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8818 | CoraFluor™ 2, Haloalkane | Dec 2024 |
| Cell permeable terbium cryptate FRET donor for TR-FRET assay development, with chloroalkane ligand | ||
| 8817 | CoraFluor™ 1, Haloalkane | Dec 2024 |
| Cell impermeable terbium cryptate FRET donor for TR-FRET assay development, with chloroalkane ligand | ||
Calcium Binding Proteins | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7877 | SGC CAMKK2-1 | Jan 2025 |
| Potent and selective CAMKK1/2 inhibitor | ||
Biochemicals and Molecular Biology | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7784 | Digoxigenin NHS ester | Jan 2025 |
| NHS ester hapten for labeling amino groups | ||
Other Degraders | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8802 | MPD 2 | Dec 2024 |
| SARS-CoV-2 Mpro Degrader (PROTAC®) | ||
| 8824 | PDEδ ATTEC 12C | Nov 2024 |
| PDEδ autophagy-tethering compound (ATTEC) Degrader | ||
Kinase Degraders | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8116 | PPM-3 | Mar 2025 |
| Potent and selective ERK5 Degrader (PROTAC®) | ||
| 8030 | JNJ 1013NC | Feb 2025 |
| Negative control for the IRAK1 degrader JNJ 1013 (Cat. No. 8029) | ||
Other Degraders | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8073 | MS 6105 | Nov 2024 |
| Potent lactate dehydrogenase Degrader (PROTAC®) | ||
Kinase Degraders | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8081 | MS 143 | Jan 2025 |
| AKT kinase Degrader (PROTAC®) | ||
| 8856 | NX 5948 | Dec 2024 |
| Potent and selective BTK Degrader (PROTAC®) | ||
Other Degraders | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8080 | MS 4322 | Dec 2024 |
| Selective PRMT5 Degrader (PROTAC®) | ||
Other Dehydrogenases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8039 | BI 3231 | Oct 2024 |
| Potent and selective hydroxysteroid 17β dehydrogenase 13 (HSD17B13) inhibitor | ||
Histone Demethylases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8167 | 193 D7 | Feb 2025 |
| JMJD1C inhibitor | ||
DNA-Dependent Protein Kinase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 5834 | LTURM 34 | Mar 2025 |
| Potent DNA-PK inhibitor; also increases CRISPR-Cas9 deletion efficiency | ||
Deubiquitinating Enzymes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7984 | BAY 805 | Feb 2025 |
| Potent and selective inhibitor of USP21; also NF-κB activator | ||
Protein Dimerizers | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8010 | SB 24011 | Oct 2024 |
| Inhibitor of STING-TRIM29 interaction; increases cellular STING levels | ||
DNA, RNA and Protein Synthesis | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7942 | Lac-Phe | Feb 2025 |
| Metabolite generated by cytosol nonspecific dipeptidase (CNDP2) during intense exercise | ||
Sulfhydryl-Reactive Janelia Fluor® Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8162 | JFX™ 650, Maleimide | Oct 2024 |
| Deuterated Janelia Fluor® dye (Reactive group: Maleimide). Application: confocal microscopy, super resolution microscopy (SRM) including dSTORM & STED. Suitable for live cell imaging | ||
| 8097 | Janelia Fluor® 669, Maleimide | Sep 2024 |
| Red dye (Reactive group: maleimide). Application: flow cytometry, confocal microscopy, super resolution microscopy including dSTORM & STED. Suitable for live cell imaging | ||
| 8025 | Janelia Fluor® 525, Maleimide | Feb 2025 |
| Yellow dye (Reactive group: maleimide). Application: flow cytometry, confocal microscopy, super resolution microscopy including dSTORM & STED. Suitable for live cell imaging | ||
| 8160 | JFX™ 554, Maleimide | Oct 2024 |
| Deuterated Janelia Fluor® dye (Reactive group: Maleimide). Application: confocal microscopy, super-resolution microscopy (SRM) including dSTORM & STED. Suitable for live cell imaging | ||
Photoactivatable Janelia Fluor® Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8133 | PA Janelia Fluor® 646, Maleimide | Feb 2025 |
| Red photoactivatable dye (Reactive group: maleimide). Application: flow cytometry, confocal microscopy, super resolution microscopy including dSTORM & STED. Suitable for live cell imaging | ||
Viral Transduction Enhancers | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8822 | Protamine sulfate | Mar 2025 |
| Transduction efficiency enhancer, also apelin receptor antagonist | ||
Other Transcription Factors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8168 | DHC-156 | Dec 2024 |
| Brachyury down modulator | ||
Fluorescent Lysosome Probes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8831 | HB-2-30 | Dec 2024 |
| Fluorescent TG2/LRP1 substrate for imaging endocytosis | ||
Fluorescent RNA Probes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8813 | RNA Imaging Probe 1c | Oct 2024 |
| Fluorogenic RNA imaging probe | ||
Molecular Glues | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8141 | SJ 3149 | Mar 2025 |
| Potent and selective CK1α molecular glue Degrader | ||
| 8129 | IBG3 | Jan 2025 |
| Potent molecular glue Degrader of BET proteins BRD4 and BRD2 | ||
Glycobiology Probes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8830 | CD22L-N3 (BPC-Sia-LacNAc-N3) | Dec 2024 |
| CD22 ligand with azide group for onward chemistry | ||
Gonadotropin-Releasing Hormone Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8821 | Cetrorelix acetate | Feb 2025 |
| Potent GnRH receptor antagonist | ||
Self-labeling Tags | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8809 | Janelia Fluor® 646, Haloalkane | Oct 2024 |
| Cell-permeable fluorogenic fluorescent dye with a chloroalkane handle. Application: live-cell imaging as a self-labeling tag substrate | ||
| 8808 | Janelia Fluor® 635, Haloalkane | Oct 2024 |
| Cell-permeable fluorogenic fluorescent dye with a chloroalkane handle. Application: live-cell imaging as a self-labeling tag substrate | ||
| 8806 | Janelia Fluor® 549, Haloalkane | Nov 2024 |
| Cell-permeable fluorogenic fluorescent dye with a chloroalkane handle. Application: live-cell imaging as a self-labeling tag substrate | ||
| 8805 | Janelia Fluor® 525, Haloalkane | Nov 2024 |
| Cell-permeable fluorogenic fluorescent dye with a chloroalkane handle. Application: live-cell imaging as a self-labeling tag substrate | ||
| 8815 | PA Janelia Fluor® 646, Haloalkane | Dec 2024 |
| Photoactivatable Janelia Fluor® 646 with chloroalkane handle for self-labeling tags fusion protein | ||
| 8807 | Janelia Fluor® 585, Haloalkane | Nov 2024 |
| Cell-permeable fluorogenic fluorescent dye with a chloroalkane handle. Application: live-cell imaging as a self-labeling tag substrate | ||
Lipid Nanoparticles | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8838 | DSPE-PEG 2000 Biotin | Feb 2025 |
| Biotinylated DSPE PEG lipid | ||
| 8889 | MC3 LNP Luciferase | Mar 2025 |
| Dlin-MC3 containing LNP for in vitro and in vivo deliver of luciferase mRNA | ||
| 8837 | DSPE-PEG 2000 Azide | Feb 2025 |
| PEGylated DSPE with azide reactive group | ||
Matrix Metalloproteases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8842 | BI 4394 | Jan 2025 |
| Highly potent and selective MMP-13 inhibitor | ||
Monocarboxylate Transporters | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8008 | MSC 4381 | Sep 2024 |
| Potent and selective monocarboxylate transporter 4 (MCT4) inhibitor | ||
Myosin | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8804 | para-Nitroblebbistatin | Feb 2025 |
| Selective inhibitor of myosin II ATPase activity. Non-cytotoxic version of (±)-Blebbistatin (Cat. No. 1760) | ||
Other Transferases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8113 | BAY 593 | Dec 2024 |
| Geranylgeranyltransferase-I (GGTase-I) inhibitor | ||
Other Proteases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7496 | FMK 9a | Nov 2024 |
| Potent ATG4B/autophagin-1 inhibitor; also inhibits calpain and cathepsin B | ||
Telomerase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8825 | TAC | Mar 2025 |
| TERT activator | ||