New ProductsView all New Products by pharmacological action
Search for new products by date added, alphabetically, or by pharmacological action.
New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the New symbol.
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Bromodomain (BRD) Degraders | ||
| Cat. No. | Product Name / Activity | Date Added |
|---|---|---|
| 8152 | JQ dS-4 | Oct 2024 |
| BRG1/SMARCA4 Degrader (PROTAC®) | ||
Histone Deacetylase (HDAC) Degraders | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8083 | JPS016 | Jul 2024 |
| Selective class I HDAC Degrader (PROTAC®) | ||
Inward Rectifier Potassium (Kir) Channels | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8151 | VU 0542270 | Sep 2024 |
| Selective inhibitor of Kir6.1 KATP channels | ||
Polycomb Repressive Complex (PRC) Degraders | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8077 | MS 147 | Jul 2024 |
| PRC1 Degrader (PROTAC®); degrades BMI1 and RING1B | ||
Glucagon-Like Peptide 1 Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7959 | LSN 3318839 | Sep 2024 |
| Glucagon-like peptide-1 receptor (GLP1-R) positive allosteric modulator | ||
EZH2 | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8093 | Tazemetostat | Sep 2024 |
| Potent and selective EZH2 inhibitor | ||
Glycogen Synthase Kinase 3 | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8170 | CHIR 99021 in solution | Oct 2024 |
| Sterile-filtered 10 mM solution of CHIR 99021 pre-dissolved in DMSO | ||
Ubiquitin E3 Ligases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8044 | CHIPOpt | Aug 2024 |
| CHIP/STUB1 E3 ligase inhibitor | ||
BMP and Other Activin Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8150 | LDN 193189 in solution | Aug 2024 |
| Sterile-filtered 10 mM solution of LDN 193189 pre-dissolved in water | ||
Amine-Reactive Janelia Fluor® Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8163 | JFX™ 650, NHS ester | Sep 2024 |
| Deuterated Janelia Fluor® dye (Reactive group: NHS ester). Application: confocal microscopy, super resolution microscopy (SRM) including dSTORM & STED. Suitable for live cell imaging | ||
Ancillary Material Grade Small Molecules | ||
| Cat. No. | Product Name / Activity | Date Added |
| TB0695-RMU | Retinoic acid | Nov 2024 |
| Retinoic acid synthesized to Ancillary Material Grade | ||
Inhibitor of Apoptosis | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8065 | CST 530 | Jan 2025 |
| Monovalent IAP antagonist | ||
| 8018 | 142D6 | Nov 2024 |
| Potent Lys-covalent pan-IAP inhibitor | ||
| 8069 | XIAP Tracer mF-Smac | Jul 2024 |
| Fluorescein labeled XIAP ligand for TR-FRET assay development | ||
TR-FRET and FP Assay Reagents | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8117 | CoraFluor™ 1, thiol reactive | Jul 2024 |
| Terbium cryptate FRET donor for TR-FRET assay development, cysteine reactive for conjugation | ||
| 7970 | SAHA-FITC | Aug 2024 |
| Fluorescent HDAC1/2 probe; suitable for use in TR-FRET and FP assays | ||
| 8818 | CoraFluor™ 2, Haloalkane | Dec 2024 |
| Cell permeable terbium cryptate FRET donor for TR-FRET assay development, with chloroalkane ligand | ||
| 8817 | CoraFluor™ 1, Haloalkane | Dec 2024 |
| Cell impermeable terbium cryptate FRET donor for TR-FRET assay development, with chloroalkane ligand | ||
Biochemicals and Molecular Biology | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7900 | SCOTfluor 510 Fmoc-Dapa-OH | Jul 2024 |
| Fmoc protected fluorescent amino acid for use in solid-phase peptide synthesis to prepare PAINT imaging probes | ||
| 7784 | Digoxigenin NHS ester | Jan 2025 |
| NHS ester hapten for labeling amino groups | ||
Chemokine CXC Receptors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8095 | LIH 383 | Aug 2024 |
| Atypical chemokine receptor (ACKR3) agonist | ||
Click-Reactive Janelia Fluor® Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8134 | Janelia Fluor® 635, Tetrazine | Aug 2024 |
| Red dye (Reactive group: tetrazine). Application: confocal microscopy, super resolution microscopy including dSTORM & STED. Suitable for live cell imaging | ||
Other Degraders | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8073 | MS 6105 | Nov 2024 |
| Potent lactate dehydrogenase Degrader (PROTAC®) | ||
| 8079 | MS 159 | Sep 2024 |
| NSD2 Degrader (PROTAC®) | ||
Kinase Degraders | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8081 | MS 143 | Jan 2025 |
| AKT kinase Degrader (PROTAC®) | ||
| 8856 | NX 5948 | Dec 2024 |
| Potent and selective BTK Degrader (PROTAC®) | ||
Other Degraders | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8802 | MPD 2 | Dec 2024 |
| SARS-CoV-2 Mpro Degrader (PROTAC®) | ||
| 8824 | PDEδ ATTEC 12C | Nov 2024 |
| PDEδ autophagy-tethering compound (ATTEC) Degrader | ||
| 8080 | MS 4322 | Dec 2024 |
| Selective PRMT5 Degrader (PROTAC®) | ||
Other Dehydrogenases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8039 | BI 3231 | Oct 2024 |
| Potent and selective hydroxysteroid 17β dehydrogenase 13 (HSD17B13) inhibitor | ||
Protein Dimerizers | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8010 | SB 24011 | Oct 2024 |
| Inhibitor of STING-TRIM29 interaction; increases cellular STING levels | ||
Sulfhydryl-Reactive Janelia Fluor® Dyes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8162 | JFX™ 650, Maleimide | Oct 2024 |
| Deuterated Janelia Fluor® dye (Reactive group: Maleimide). Application: confocal microscopy, super resolution microscopy (SRM) including dSTORM & STED. Suitable for live cell imaging | ||
| 8160 | JFX™ 554, Maleimide | Oct 2024 |
| Deuterated Janelia Fluor® dye (Reactive group: Maleimide). Application: confocal microscopy, super-resolution microscopy (SRM) including dSTORM & STED. Suitable for live cell imaging | ||
| 8097 | Janelia Fluor® 669, Maleimide | Sep 2024 |
| Red dye (Reactive group: maleimide). Application: flow cytometry, confocal microscopy, super resolution microscopy including dSTORM & STED. Suitable for live cell imaging | ||
Other Transcription Factors | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8168 | DHC-156 | Dec 2024 |
| Brachyury down modulator | ||
Fluorescent Lysosome Probes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8831 | HB-2-30 | Dec 2024 |
| Fluorescent TG2/LRP1 substrate for imaging endocytosis | ||
Fluorescent RNA Probes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8813 | RNA Imaging Probe 1c | Oct 2024 |
| Fluorogenic RNA imaging probe | ||
Other Fluorescent Probes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8126 | Mpro Tracer | Aug 2024 |
| SARS-CoV-2 main protease fluorescent ligand; TR-FRET acceptor | ||
| 8045 | FITC-CHIPOpt | Aug 2024 |
| Fluorescent CHIP/STUB1 E3 ligase inhibitor | ||
Glycobiology Probes | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8830 | CD22L-N3 (BPC-Sia-LacNAc-N3) | Dec 2024 |
| CD22 ligand with azide group for onward chemistry | ||
Other Kinases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8175 | NIBR LTSi | Sep 2024 |
| Potent and selective LATS inhibitor; activates YAP signaling | ||
Self-labeling Tags | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8815 | PA Janelia Fluor® 646, Haloalkane | Dec 2024 |
| Photoactivatable Janelia Fluor® 646 with chloroalkane handle for self-labeling tags fusion protein | ||
| 8809 | Janelia Fluor® 646, Haloalkane | Oct 2024 |
| Cell-permeable fluorogenic fluorescent dye with a chloroalkane handle. Application: live-cell imaging as a self-labeling tag substrate | ||
| 8808 | Janelia Fluor® 635, Haloalkane | Oct 2024 |
| Cell-permeable fluorogenic fluorescent dye with a chloroalkane handle. Application: live-cell imaging as a self-labeling tag substrate | ||
| 8807 | Janelia Fluor® 585, Haloalkane | Nov 2024 |
| Cell-permeable fluorogenic fluorescent dye with a chloroalkane handle. Application: live-cell imaging as a self-labeling tag substrate | ||
| 8806 | Janelia Fluor® 549, Haloalkane | Nov 2024 |
| Cell-permeable fluorogenic fluorescent dye with a chloroalkane handle. Application: live-cell imaging as a self-labeling tag substrate | ||
| 8805 | Janelia Fluor® 525, Haloalkane | Nov 2024 |
| Cell-permeable fluorogenic fluorescent dye with a chloroalkane handle. Application: live-cell imaging as a self-labeling tag substrate | ||
Monocarboxylate Transporters | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8008 | MSC 4381 | Sep 2024 |
| Potent and selective monocarboxylate transporter 4 (MCT4) inhibitor | ||
NTPDase | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8173 | Adenosine 5'-(α,β-methylene)diphosphate disodium salt | Aug 2024 |
| Ecto-5'-nucleotidase (CD73) inhibitor | ||
Other Transferases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8113 | BAY 593 | Dec 2024 |
| Geranylgeranyltransferase-I (GGTase-I) inhibitor | ||
Other RTKs | ||
| Cat. No. | Product Name / Activity | Date Added |
| 8023 | AZ 14145845 | Jul 2024 |
| Dual Mer/Axl inhibitor | ||
Other Proteases | ||
| Cat. No. | Product Name / Activity | Date Added |
| 7496 | FMK 9a | Nov 2024 |
| Potent ATG4B/autophagin-1 inhibitor; also inhibits calpain and cathepsin B | ||