New Products

View all New Products by pharmacological action

Search for new products by date added, alphabetically, or by pharmacological action.

New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the symbol.

If you can't find what you are looking for we welcome new product suggestions. If you would like to be kept informed about new products by email, please sign up for our monthly e-alert service.

Bromodomain (BRD) Degraders

Cat. No. Product Name / Activity Date Added
8152 JQ dS-4 Oct 2024
BRG1/SMARCA4 Degrader (PROTAC®)

Cyclin Dependent Kinase (CDK) Degraders

Cat. No. Product Name / Activity Date Added
7940 HEMTAC 26 Jan 2025
CDK6 and CDK4 HSP90-mediated targeting chimera (HEMTAC) Degrader

Inward Rectifier Potassium (Kir) Channels

Cat. No. Product Name / Activity Date Added
8151 VU 0542270 Sep 2024
Selective inhibitor of Kir6.1 KATP channels

Voltage-gated Potassium (KV) Channels

Cat. No. Product Name / Activity Date Added
8137 Ebio1 Feb 2025
KCNQ2 activator

Near Infrared (NIR) Fluorescent Dyes

Cat. No. Product Name / Activity Date Added
8881 IRDye® 800CW, NHS ester Feb 2025
Near-infared dye (reactive group NHS ester)
8879 IRDye® 800CW, DBCO Feb 2025
Near-infared dye (reactive group DBCO)
8880 IRDye® 800CW, Maleimide Feb 2025
Near-infrared dye (Reactive group: maleimide)
8877 IRDye® 680RD, Maleimide Feb 2025
Near-infared dye (reactive group maleimide)
8878 IRDye® 680RD, NHS ester Feb 2025
Near-infared dye (reactive group NHS ester)

Glucagon-Like Peptide 1 Receptors

Cat. No. Product Name / Activity Date Added
7959 LSN 3318839 Sep 2024
Glucagon-like peptide-1 receptor (GLP1-R) positive allosteric modulator

CB2 Receptors

Cat. No. Product Name / Activity Date Added
8835 RNB 61 Feb 2025
Highly potent and selective CB2R agonist

EZH2

Cat. No. Product Name / Activity Date Added
8093 Tazemetostat Sep 2024
Potent and selective EZH2 inhibitor

Glycogen Synthase Kinase 3

Cat. No. Product Name / Activity Date Added
8170 CHIR 99021 in solution Oct 2024
Sterile-filtered 10 mM solution of CHIR 99021 pre-dissolved in DMSO

Functionalized E3 Ligase Ligands

Cat. No. Product Name / Activity Date Added
8075 VHF 543, amine Feb 2025
DCAF1 WD40 ligand with terminal amine for onward chemistry

Ubiquitin E3 Ligases

Cat. No. Product Name / Activity Date Added
8091 KH-4-43 Feb 2025
Selective CUL4 inhibitor
8047 JP-2-196 alkyne Feb 2025
RNF126 chemical handle; alkyne functionalized version of JP-2-196 (Cat. No. 8046).
8046 JP-2-196 Feb 2025
RNF126 chemical handle
7960 PFI 7 Jan 2025
Selective GID4 antagonist

Orphan 7-TM Receptors

Cat. No. Product Name / Activity Date Added
8131 OX 04528 Feb 2025
Highly potent and selective GPR84 agonist

ALK

Cat. No. Product Name / Activity Date Added
8832 MU 1700 trihydrochloride Feb 2025
Potent and selective ALK1/2 inhibitor. Brain-penetrant

Ancillary Material Grade Small Molecules

Cat. No. Product Name / Activity Date Added
TB0695-RMU Retinoic acid Nov 2024
Retinoic acid synthesized to Ancillary Material Grade

Inhibitor of Apoptosis

Cat. No. Product Name / Activity Date Added
8018 142D6 Nov 2024
Potent Lys-covalent pan-IAP inhibitor
8065 CST 530 Jan 2025
Monovalent IAP antagonist

TR-FRET and FP Assay Reagents

Cat. No. Product Name / Activity Date Added
8818 CoraFluor™ 2, Haloalkane Dec 2024
Cell permeable terbium cryptate FRET donor for TR-FRET assay development, with chloroalkane ligand
8817 CoraFluor™ 1, Haloalkane Dec 2024
Cell impermeable terbium cryptate FRET donor for TR-FRET assay development, with chloroalkane ligand

Calcium Binding Proteins

Cat. No. Product Name / Activity Date Added
7877 SGC CAMKK2-1 Jan 2025
Potent and selective CAMKK1/2 inhibitor

Biochemicals and Molecular Biology

Cat. No. Product Name / Activity Date Added
7784 Digoxigenin NHS ester Jan 2025
NHS ester hapten for labeling amino groups

Other Degraders

Cat. No. Product Name / Activity Date Added
8802 MPD 2 Dec 2024
SARS-CoV-2 Mpro Degrader (PROTAC®)
8824 PDEδ ATTEC 12C Nov 2024
PDEδ autophagy-tethering compound (ATTEC) Degrader

Kinase Degraders

Cat. No. Product Name / Activity Date Added
8116 PPM-3 Mar 2025
Potent and selective ERK5 Degrader (PROTAC®)
8030 JNJ 1013NC Feb 2025
Negative control for the IRAK1 degrader JNJ 1013 (Cat. No. 8029)

Other Degraders

Cat. No. Product Name / Activity Date Added
8073 MS 6105 Nov 2024
Potent lactate dehydrogenase Degrader (PROTAC®)

Kinase Degraders

Cat. No. Product Name / Activity Date Added
8081 MS 143 Jan 2025
AKT kinase Degrader (PROTAC®)
8856 NX 5948 Dec 2024
Potent and selective BTK Degrader (PROTAC®)

Other Degraders

Cat. No. Product Name / Activity Date Added
8080 MS 4322 Dec 2024
Selective PRMT5 Degrader (PROTAC®)

Other Dehydrogenases

Cat. No. Product Name / Activity Date Added
8039 BI 3231 Oct 2024
Potent and selective hydroxysteroid 17β dehydrogenase 13 (HSD17B13) inhibitor

Histone Demethylases

Cat. No. Product Name / Activity Date Added
8167 193 D7 Feb 2025
JMJD1C inhibitor

DNA-Dependent Protein Kinase

Cat. No. Product Name / Activity Date Added
5834 LTURM 34 Mar 2025
Potent DNA-PK inhibitor; also increases CRISPR-Cas9 deletion efficiency

Deubiquitinating Enzymes

Cat. No. Product Name / Activity Date Added
7984 BAY 805 Feb 2025
Potent and selective inhibitor of USP21; also NF-κB activator

Protein Dimerizers

Cat. No. Product Name / Activity Date Added
8010 SB 24011 Oct 2024
Inhibitor of STING-TRIM29 interaction; increases cellular STING levels

DNA, RNA and Protein Synthesis

Cat. No. Product Name / Activity Date Added
7942 Lac-Phe Feb 2025
Metabolite generated by cytosol nonspecific dipeptidase (CNDP2) during intense exercise

Sulfhydryl-Reactive Janelia Fluor® Dyes

Cat. No. Product Name / Activity Date Added
8162 JFX™ 650, Maleimide Oct 2024
Deuterated Janelia Fluor® dye (Reactive group: Maleimide). Application: confocal microscopy, super resolution microscopy (SRM) including dSTORM & STED. Suitable for live cell imaging
8097 Janelia Fluor® 669, Maleimide Sep 2024
Red dye (Reactive group: maleimide). Application: flow cytometry, confocal microscopy, super resolution microscopy including dSTORM & STED. Suitable for live cell imaging
8025 Janelia Fluor® 525, Maleimide Feb 2025
Yellow dye (Reactive group: maleimide). Application: flow cytometry, confocal microscopy, super resolution microscopy including dSTORM & STED. Suitable for live cell imaging
8160 JFX™ 554, Maleimide Oct 2024
Deuterated Janelia Fluor® dye (Reactive group: Maleimide). Application: confocal microscopy, super-resolution microscopy (SRM) including dSTORM & STED. Suitable for live cell imaging

Photoactivatable Janelia Fluor® Dyes

Cat. No. Product Name / Activity Date Added
8133 PA Janelia Fluor® 646, Maleimide Feb 2025
Red photoactivatable dye (Reactive group: maleimide). Application: flow cytometry, confocal microscopy, super resolution microscopy including dSTORM & STED. Suitable for live cell imaging

Viral Transduction Enhancers

Cat. No. Product Name / Activity Date Added
8822 Protamine sulfate Mar 2025
Transduction efficiency enhancer, also apelin receptor antagonist

Other Transcription Factors

Cat. No. Product Name / Activity Date Added
8168 DHC-156 Dec 2024
Brachyury down modulator

Fluorescent Lysosome Probes

Cat. No. Product Name / Activity Date Added
8831 HB-2-30 Dec 2024
Fluorescent TG2/LRP1 substrate for imaging endocytosis

Fluorescent RNA Probes

Cat. No. Product Name / Activity Date Added
8813 RNA Imaging Probe 1c Oct 2024
Fluorogenic RNA imaging probe

Molecular Glues

Cat. No. Product Name / Activity Date Added
8141 SJ 3149 Mar 2025
Potent and selective CK1α molecular glue Degrader
8129 IBG3 Jan 2025
Potent molecular glue Degrader of BET proteins BRD4 and BRD2

Glycobiology Probes

Cat. No. Product Name / Activity Date Added
8830 CD22L-N3 (BPC-Sia-LacNAc-N3) Dec 2024
CD22 ligand with azide group for onward chemistry

Gonadotropin-Releasing Hormone Receptors

Cat. No. Product Name / Activity Date Added
8821 Cetrorelix acetate Feb 2025
Potent GnRH receptor antagonist

Self-labeling Tags

Cat. No. Product Name / Activity Date Added
8809 Janelia Fluor® 646, Haloalkane Oct 2024
Cell-permeable fluorogenic fluorescent dye with a chloroalkane handle. Application: live-cell imaging as a self-labeling tag substrate
8808 Janelia Fluor® 635, Haloalkane Oct 2024
Cell-permeable fluorogenic fluorescent dye with a chloroalkane handle. Application: live-cell imaging as a self-labeling tag substrate
8806 Janelia Fluor® 549, Haloalkane Nov 2024
Cell-permeable fluorogenic fluorescent dye with a chloroalkane handle. Application: live-cell imaging as a self-labeling tag substrate
8805 Janelia Fluor® 525, Haloalkane Nov 2024
Cell-permeable fluorogenic fluorescent dye with a chloroalkane handle. Application: live-cell imaging as a self-labeling tag substrate
8815 PA Janelia Fluor® 646, Haloalkane Dec 2024
Photoactivatable Janelia Fluor® 646 with chloroalkane handle for self-labeling tags fusion protein
8807 Janelia Fluor® 585, Haloalkane Nov 2024
Cell-permeable fluorogenic fluorescent dye with a chloroalkane handle. Application: live-cell imaging as a self-labeling tag substrate

Lipid Nanoparticles

Cat. No. Product Name / Activity Date Added
8838 DSPE-PEG 2000 Biotin Feb 2025
Biotinylated DSPE PEG lipid
8889 MC3 LNP Luciferase Mar 2025
Dlin-MC3 containing LNP for in vitro and in vivo deliver of luciferase mRNA
8837 DSPE-PEG 2000 Azide Feb 2025
PEGylated DSPE with azide reactive group

Matrix Metalloproteases

Cat. No. Product Name / Activity Date Added
8842 BI 4394 Jan 2025
Highly potent and selective MMP-13 inhibitor

Monocarboxylate Transporters

Cat. No. Product Name / Activity Date Added
8008 MSC 4381 Sep 2024
Potent and selective monocarboxylate transporter 4 (MCT4) inhibitor

Myosin

Cat. No. Product Name / Activity Date Added
8804 para-Nitroblebbistatin Feb 2025
Selective inhibitor of myosin II ATPase activity. Non-cytotoxic version of (±)-Blebbistatin (Cat. No. 1760)

Other Transferases

Cat. No. Product Name / Activity Date Added
8113 BAY 593 Dec 2024
Geranylgeranyltransferase-I (GGTase-I) inhibitor

Other Proteases

Cat. No. Product Name / Activity Date Added
7496 FMK 9a Nov 2024
Potent ATG4B/autophagin-1 inhibitor; also inhibits calpain and cathepsin B

Telomerase

Cat. No. Product Name / Activity Date Added
8825 TAC Mar 2025
TERT activator