New ProductsView all New Products by pharmacological action
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New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the New symbol.
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| 8811 | ESI 1 | Apr 2025 |
Cyclin Dependent Kinase (CDK) Degraders | ||
| Cat. No. | 产品名称/活性 | Date Added |
|---|---|---|
| 7940 | HEMTAC 26 | Jan 2025 |
| CDK6 and CDK4 HSP90-mediated targeting chimera (HEMTAC) Degrader | ||
Voltage-gated Potassium (KV) Channels | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8137 | Ebio1 | Feb 2025 |
| KCNQ2 activator | ||
Near Infrared (NIR) Fluorescent Dyes | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8880 | IRDye® 800CW, Maleimide | Feb 2025 |
| Near-infrared dye (Reactive group: maleimide) | ||
| 8877 | IRDye® 680RD, Maleimide | Feb 2025 |
| Near-infared dye (reactive group maleimide) | ||
| 8878 | IRDye® 680RD, NHS ester | Feb 2025 |
| Near-infared dye (reactive group NHS ester) | ||
| 8881 | IRDye® 800CW, NHS ester | Feb 2025 |
| Near-infared dye (reactive group NHS ester) | ||
| 8879 | IRDye® 800CW, DBCO | Feb 2025 |
| Near-infared dye (reactive group DBCO) | ||
CB2 Receptors | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8835 | RNB 61 | Feb 2025 |
| Highly potent and selective CB2R agonist | ||
Ubiquitin E3 Ligases | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8091 | KH-4-43 | Feb 2025 |
| Selective CUL4 inhibitor | ||
| 8047 | JP-2-196 alkyne | Feb 2025 |
| RNF126 chemical handle; alkyne functionalized version of JP-2-196 (Cat. No. 8046). | ||
Functionalized E3 Ligase Ligands | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8075 | VHF 543, amine | Feb 2025 |
| DCAF1 WD40 ligand with terminal amine for onward chemistry | ||
Ubiquitin E3 Ligases | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 7960 | PFI 7 | Jan 2025 |
| Selective GID4 antagonist | ||
| 8046 | JP-2-196 | Feb 2025 |
| RNF126 chemical handle | ||
Orphan 7-TM Receptors | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8131 | OX 04528 | Feb 2025 |
| Highly potent and selective GPR84 agonist | ||
Free Acid Janelia Fluor® Dyes | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8915 | Janelia Fluor® 646, free acid | Apr 2025 |
| Red dye (Reactive group: free acid). Application: flow cytometry, confocal microscopy, super resolution microscopy (SRM) including dSTORM & STED. Suitable for live cell imaging | ||
ALK | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8832 | MU 1700 trihydrochloride | Feb 2025 |
| Potent and selective ALK1/2 inhibitor. Brain-penetrant | ||
Ancillary Material Grade Small Molecules | ||
| Cat. No. | 产品名称/活性 | Date Added |
| TB0695-RMU | Retinoic acid | Nov 2024 |
| Retinoic acid synthesized to Ancillary Material Grade | ||
Inhibitor of Apoptosis | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8065 | CST 530 | Jan 2025 |
| Monovalent IAP antagonist | ||
| 8018 | 142D6 | Nov 2024 |
| Potent Lys-covalent pan-IAP inhibitor | ||
TR-FRET and FP Assay Reagents | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8818 | CoraFluor™ 2, Haloalkane | Dec 2024 |
| Cell permeable terbium cryptate FRET donor for TR-FRET assay development, with chloroalkane ligand | ||
| 8817 | CoraFluor™ 1, Haloalkane | Dec 2024 |
| Cell impermeable terbium cryptate FRET donor for TR-FRET assay development, with chloroalkane ligand | ||
Calcium Binding Proteins | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 7877 | SGC CAMKK2-1 | Jan 2025 |
| Potent and selective CAMKK1/2 inhibitor | ||
Biochemicals and Molecular Biology | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 7784 | Digoxigenin NHS ester | Jan 2025 |
| NHS ester hapten for labeling amino groups | ||
| 8869 | ArMan | Apr 2025 |
| DC-SIGN ligand used to target dendritic cells | ||
Cereblon Targeting Ligands Plus Linkers | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8848 | Lenalidomide 5'-piperazine-7'-methoxy | Apr 2025 |
| Cereblon ligand with terminal piperazine for onward chemistry | ||
Other Degraders | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8854 | KL 465 | Mar 2025 |
| MAGE-A3 Degrader (PROTAC®) | ||
| 8891 | CRBN5-SNAP2-1C-PIP | Mar 2025 |
| Degrader (PROTAC®) of SNAP-tag™ labeled fusion proteins | ||
Kinase Degraders | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8081 | MS 143 | Jan 2025 |
| AKT kinase Degrader (PROTAC®) | ||
| 8856 | NX 5948 | Dec 2024 |
| Potent and selective BTK Degrader (PROTAC®) | ||
Other Degraders | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8080 | MS 4322 | Dec 2024 |
| Selective PRMT5 Degrader (PROTAC®) | ||
| 8802 | MPD 2 | Dec 2024 |
| SARS-CoV-2 Mpro Degrader (PROTAC®) | ||
| 8824 | PDEδ ATTEC 12C | Nov 2024 |
| PDEδ autophagy-tethering compound (ATTEC) Degrader | ||
Kinase Degraders | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8116 | PPM-3 | Mar 2025 |
| Potent and selective ERK5 Degrader (PROTAC®) | ||
| 8030 | JNJ 1013NC | Feb 2025 |
| Negative control for the IRAK1 degrader JNJ 1013 (Cat. No. 8029) | ||
Other Degraders | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8890 | VHL-SNAP2-5C | Mar 2025 |
| Degrader (PROTAC®) of SNAP-tag™ labeled fusion proteins | ||
| 7964 | hCAII Degrader 11 | Mar 2025 |
| Potent human carbonic anhydrase II Degrader (PROTAC®) | ||
| 8073 | MS 6105 | Nov 2024 |
| Potent lactate dehydrogenase Degrader (PROTAC®) | ||
Histone Demethylases | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8167 | 193 D7 | Feb 2025 |
| JMJD1C inhibitor | ||
DNA-Dependent Protein Kinase | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 5834 | LTURM 34 | Mar 2025 |
| Potent DNA-PK inhibitor; also increases CRISPR-Cas9 deletion efficiency | ||
Deubiquitinating Enzymes | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 7984 | BAY 805 | Feb 2025 |
| Potent and selective inhibitor of USP21; also NF-κB activator | ||
Protein Dimerizers | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8010 | SB 24011 | Oct 2024 |
| Inhibitor of STING-TRIM29 interaction; increases cellular STING levels | ||
DNA, RNA and Protein Synthesis | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 7942 | Lac-Phe | Feb 2025 |
| Metabolite generated by cytosol nonspecific dipeptidase (CNDP2) during intense exercise | ||
Photoactivatable Janelia Fluor® Dyes | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8133 | PA Janelia Fluor® 646, Maleimide | Feb 2025 |
| Red photoactivatable dye (Reactive group: maleimide). Application: flow cytometry, confocal microscopy, super resolution microscopy including dSTORM & STED. Suitable for live cell imaging | ||
Sulfhydryl-Reactive Janelia Fluor® Dyes | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8025 | Janelia Fluor® 525, Maleimide | Feb 2025 |
| Yellow dye (Reactive group: maleimide). Application: flow cytometry, confocal microscopy, super resolution microscopy including dSTORM & STED. Suitable for live cell imaging | ||
Viral Transduction Enhancers | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8822 | Protamine sulfate | Mar 2025 |
| Transduction efficiency enhancer, also apelin receptor antagonist | ||
Other Transcription Factors | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8168 | DHC-156 | Dec 2024 |
| Brachyury down modulator | ||
Fluorescent Lysosome Probes | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8831 | HB-2-30 | Dec 2024 |
| Fluorescent TG2/LRP1 substrate for imaging endocytosis | ||
Other Fluorescent Probes | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8086 | Acridonylalanine | Apr 2025 |
| Fluorescent unnatural amino acid. | ||
Molecular Glues | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8141 | SJ 3149 | Mar 2025 |
| Potent and selective CK1α molecular glue Degrader | ||
| 8129 | IBG3 | Jan 2025 |
| Potent molecular glue Degrader of BET proteins BRD4 and BRD2 | ||
Glycobiology Probes | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8830 | CD22L-N3 (BPC-Sia-LacNAc-N3) | Dec 2024 |
| CD22 ligand with azide group for onward chemistry | ||
Gonadotropin-Releasing Hormone Receptors | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8821 | Cetrorelix acetate | Feb 2025 |
| Potent GnRH receptor antagonist | ||
Other Ion Pumps/Transporters | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8057 | V 9302 hydrochloride | Mar 2025 |
| ASCT2 (SLC1A5) inhibitor | ||
Rho-Kinases | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 7881 | CHDI 00580985 | Mar 2025 |
| Potent and selective ROCK inhibitor; orally bioavailable and brain penetrant | ||
Self-labeling Tags | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8815 | PA Janelia Fluor® 646, Haloalkane | Dec 2024 |
| Photoactivatable Janelia Fluor® 646 with chloroalkane handle for self-labeling tags fusion protein | ||
| 8809 | Janelia Fluor® 646, Haloalkane | Oct 2024 |
| Cell-permeable fluorogenic fluorescent dye with a chloroalkane handle. Application: live-cell imaging as a self-labeling tag substrate | ||
| 8808 | Janelia Fluor® 635, Haloalkane | Oct 2024 |
| Cell-permeable fluorogenic fluorescent dye with a chloroalkane handle. Application: live-cell imaging as a self-labeling tag substrate | ||
| 8807 | Janelia Fluor® 585, Haloalkane | Nov 2024 |
| Cell-permeable fluorogenic fluorescent dye with a chloroalkane handle. Application: live-cell imaging as a self-labeling tag substrate | ||
| 8806 | Janelia Fluor® 549, Haloalkane | Nov 2024 |
| Cell-permeable fluorogenic fluorescent dye with a chloroalkane handle. Application: live-cell imaging as a self-labeling tag substrate | ||
| 8805 | Janelia Fluor® 525, Haloalkane | Nov 2024 |
| Cell-permeable fluorogenic fluorescent dye with a chloroalkane handle. Application: live-cell imaging as a self-labeling tag substrate | ||
Lipid Nanoparticles | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8837 | DSPE-PEG 2000 Azide | Feb 2025 |
| PEGylated DSPE with azide reactive group | ||
| 8838 | DSPE-PEG 2000 Biotin | Feb 2025 |
| Biotinylated DSPE PEG lipid | ||
| 8889 | MC3 LNP Luciferase | Mar 2025 |
| Dlin-MC3 containing LNP for in vitro and in vivo delivery of luciferase mRNA | ||
Matrix Metalloproteases | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8842 | BI 4394 | Jan 2025 |
| Highly potent and selective MMP-13 inhibitor | ||
Myosin | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8804 | para-Nitroblebbistatin | Feb 2025 |
| Selective inhibitor of myosin II ATPase activity. Non-cytotoxic version of (±)-Blebbistatin (Cat. No. 1760) | ||
Other Proteases | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 7496 | FMK 9a | Nov 2024 |
| Potent ATG4B/autophagin-1 inhibitor; also inhibits calpain and cathepsin B | ||
Other Transferases | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8113 | BAY 593 | Dec 2024 |
| Geranylgeranyltransferase-I (GGTase-I) inhibitor | ||
Telomerase | ||
| Cat. No. | 产品名称/活性 | Date Added |
| 8825 | TAC | Mar 2025 |
| TERT activator | ||